Homotypic and heterotypic Ca++-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface
| Autor: | Goro Kosaki, Motomu Kuroki, Shinzo Oikawa, Yuji Matsuoka, Hiroshi Nakazato |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Biophysics
CHO Cells Biology Transfection Biochemistry Carcinoembryonic antigen Antigen Antigens CD Cricetinae Cell Adhesion Leukocytes Animals Humans Cell adhesion Molecular Biology Cell Aggregation Gene Library Glycoproteins chemistry.chemical_classification Chinese hamster ovary cell Cell Membrane Cell Biology Adhesion Molecular biology Recombinant Proteins In vitro Carcinoembryonic Antigen chemistry biology.protein Calcium Glycoprotein Cell Adhesion Molecules |
| Zdroj: | Biochemical and Biophysical Research Communications. 186:881-887 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(92)90828-9 |
| Popis: | Homotypic and heterotypic cell adhesion activities of a carcinoembryonic antigen (CEA) family member, biliary glycoprotein a (BGPa), have been examined. CHO cells transfected with the cDNA for BGPa, CEA, non-specific cross-reacting antigen (NCA) and CGM6 have been used. The BGPa producers showed both homotypic and heterotypic adhesion to CEA and NCA producers. However, they hardly adhered to CGM6 producers. Calcium ion was not required for BGPa-mediated homotypic and heterotypic cell adhesion as well as for the adhesions of other members of CEA family. The results strongly suggested that BGPa may play some important roles through Ca ++ -independent cell adhesion activities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|