Dynamics of tissue shrinkage during ablative temperature exposures
| Autor: | Elizabeth Garrett-Mayer, Dieter Haemmerich, Frank Rattay, Christian Rossmann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Ablation Techniques
Materials science Time Factors Physiology Radiofrequency ablation Swine medicine.medical_treatment Biomedical Engineering Biophysics Models Biological Isothermal process Article law.invention law Physiology (medical) Ablative case medicine Animals Shrinkage Microwave ablation Temperature Organ Size Ablation Liver Biomedical engineering |
| Popis: | There is a lack of studies that examine the dynamics of heat-induced shrinkage of organ tissues. Clinical procedures such as radiofrequency ablation, microwave ablation or high-intensity focused ultrasound, use heat to treat diseases such as cancer and cardiac arrhythmia. When heat is applied to tissues, shrinkage occurs due to protein denaturation, dehydration and contraction of collagen at temperatures greater 50 °C. This is particularly relevant for image-guided procedures such as tumor ablation, where pre- and post-treatment images are compared and any changes in dimensions must be considered to avoid misinterpretations of the treatment outcome. We present data from ex vivo, isothermal shrinkage tests in porcine liver tissue, where axial changes in tissue length were recorded during 15 min of heating to temperatures between 60 and 95 °C. A mathematical model was developed to accurately describe the time and temperature-dependent shrinkage behavior. The shrinkage dynamics had the same characteristics independent of temperature; the estimated relative shrinkage, adjusted for time since death, after 15 min heating to temperatures of 60, 65, 75, 85 and 95 °C, was 12.3, 13.8, 16.6, 19.2 and 21.7%, respectively. Our results demonstrate the shrinkage dynamics of organ tissues, and suggest the importance of considering tissue shrinkage for thermal ablative treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|