Association of Angiotensin-Converting Enzyme Gene Polymorphism with Lipid Profiles in Children and Adolescents with Insulin-Dependent Diabetes mellitus
| Autor: | Emi Sawanobori, Mie Mochizuki, Koji Kobayashi, Toshihide Ishihara, Kyoko Matsushita, Yoshie Shimura, Kiyohiko Kato, Kosuke Higashida, Shin Amemiya, Kisho Kobayashi, Shinpei Nakazawa |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Genotype Endocrinology Diabetes and Metabolism Peptidyl-Dipeptidase A Endocrinology Internal medicine medicine Humans Alleles Apolipoproteins B chemistry.chemical_classification Polymorphism Genetic Apolipoprotein A-I biology business.industry Angiotensin-converting enzyme Lipoprotein(a) Lipids Diabetes Mellitus Type 1 Enzyme chemistry Insulin dependent diabetes Pediatrics Perinatology and Child Health biology.protein Regression Analysis Female Gene polymorphism business |
| Zdroj: | Hormone Research in Paediatrics. 51:201-204 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000023358 |
| Popis: | We attempted to clarify the association between angiotensin-converting enzyme (ACE) gene polymorphism and the other predictive factors for macroangiopathy in children and adolescents with uncomplicated insulin-dependent diabetes mellitus (IDDM). Sixty-three patients were divided into 3 groups according to the ACE genotypes. The lipid profiles were evaluated according to ACE genotypes. The level of lipoprotein(a) (Lp(a)) in the II genotype was significantly lower than that in groups with the D allele. Lp(a) significantly correlated with apo B/apo A-I (p < 0.001, r = 0.63) and atherogenic index (AI = (total cholesterol – high-density lipoprotein cholesterol)/high-density lipoprotein cholesterol; p = 0.004, r = 0.36). We suggest that the D allele may affect the level of Lp(a) and the other lipid profiles in IDDM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|