Hypoglycaemic role of wheatgrass and its effect on carbohydrate metabolic enzymes in type II diabetic rats
| Autor: | Sankar Pajaniradje, Praveen Kumar Randhi, Garima Shakya, Kumaravel Mohankumar, Rukkumani Rajagopalan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment 030209 endocrinology & metabolism Glucosephosphate Dehydrogenase Toxicology Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus Hexokinase medicine Glucose-6-phosphate dehydrogenase Animals Hypoglycemic Agents Insulin Rats Wistar Triticum Glycogen business.industry Public Health Environmental and Occupational Health 04 agricultural and veterinary sciences Carbohydrate medicine.disease Prognosis 040401 food science Liver Glycogen Rats Endocrinology chemistry Diabetes Mellitus Type 2 Liver Hyperglycemia Plant Preparations business |
| Zdroj: | Toxicology and industrial health. 32(6) |
| ISSN: | 1477-0393 |
| Popis: | Diabetes mellitus (DM) is a leading cause of morbidity and mortality in the world. Insulin resistance and insulin insufficiency is the major factor for the prognosis of type II diabetes. Consistent high glucose level leads to multiple secondary complications in diabetic patients. Hence, hypoglycaemic drugs are of significance for reducing the risk of secondary complications in type II diabetes. Various hypoglycaemic drugs are already available in the market, but they are associated with several side effects. Therefore, traditional herbs have emerged as safer alternative for effective hypoglycaemic treatment. The juvenile grass of common wheat is known as wheatgrass (WG). It is commonly used as a health drink and has potent antioxidant efficacy. It has been used to cure DM in folk medicine. The current study was planned to test the hypoglycaemic effect and pathways regulated by WG on DM. We analysed the glucose and insulin levels in plasma, the activity of glucose oxidative enzymes, hexokinase and glucose 6 phosphate dehydrogenase, in serum and glycogen levels in liver of the male albino Wistar rats. Activity of glucose oxidative enzymes and the levels of insulin and liver glycogen were decreased in rats with diabetes, but they were reversed on treatment with WG. Hence, we conclude that WG can act as a potent anti-hyperglycaemic agent. |
| Databáze: | OpenAIRE |
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