Treatment planning for laser-accelerated very-high energy electrons
| Autor: | H. Szymanowski, Uwe Oelfke, Y. Glinec, Clément Rechatin, Victor Malka, T. Fuchs, Jérôme Faure |
|---|---|
| Přispěvatelé: | Deutsches Krebsforschungszentrum Heidelberg, Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Photon [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] Monte Carlo method quantum optics and lasers Electrons Electron 030218 nuclear medicine & medical imaging law.invention Plasma physics Radiotherapy High-Energy 03 medical and health sciences Magnetics PACS 87.53.Bn 87.56.ng 42.62.Be 87.55.-x 52.77.-j 0302 clinical medicine Optics law Humans Radiology Nuclear Medicine and imaging Computer Simulation Radiation treatment planning Physics Radiological and Ultrasound Technology business.industry Penumbra Lasers Radiotherapy Planning Computer-Assisted Prostatic Neoplasms Water Radiotherapy Dosage Laser 030220 oncology & carcinogenesis Cathode ray [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] Medical physics business Monte Carlo Method Biological physics Beam (structure) |
| Zdroj: | Physics in Medicine and Biology Physics in Medicine and Biology, IOP Publishing, 2009, 54 (11), pp.3315. ⟨10.1088/0031-9155/54/11/003⟩ |
| ISSN: | 0031-9155 1361-6560 |
| DOI: | 10.1088/0031-9155/54/11/003⟩ |
| Popis: | International audience; In recent experiments, quasi-monoenergetic and well-collimated very-high energy electron (VHEE) beams were obtained by laser–plasma accelerators. We investigate their potential use for radiation therapy. Monte Carlo simulations are used to study the influence of the experimental characteristics such as beam energy, energy spread and initial angular distribution on the dose distributions. It is found that magnetic focusing of the electron beam improves the lateral penumbra. The dosimetric properties of the laser-accelerated VHEE beams are implemented in our inverse treatment planning system for intensity-modulated treatments. The influence of the beam characteristics on the quality of a prostate treatment plan is evaluated. In comparison to a clinically approved 6 MV IMRT photon plan, a better target coverage is achieved. The quality of the sparing of organs at risk is found to be dependent on the depth. The bladder and rectum are better protected due to the sharp lateral penumbra at low depths, whereas the femoral heads receive a larger dose because of the large scattering amplitude at larger depths. |
| Databáze: | OpenAIRE |
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