Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education

Autor: I.S.M. van der Wurff, Trygve Bergeland, R.H.M. de Groot, Paul A. Kirschner, Ruslan Leontjevas, Maurice P. Zeegers, C. von Schacky
Přispěvatelé: RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: CAPHRI - R5 - Optimising Patient Care, Complexe Genetica, RS-Theme Biopsychology of Learning, Department FEEEL, RS-Research Line Fostering Effective, Efficient and Enjoyable Learning (FEEEL) (part of WO program), Section Methodology & Statistics, RS-Research Program The Interaction between Implicit and Explicit Strategies for Behaviour (IIESB), Distinguished University Professors, RS-Research Line Methodology & statistics (part of IIESB program)
Rok vydání: 2019
Předmět:
0301 basic medicine
Secondary education
EICOSAPENTAENOIC ACID
media_common.quotation_subject
Medicine (miscellaneous)
ITEM RESPONSE THEORY
030209 endocrinology & metabolism
Omega 3 index
Adolescents
High schoolers
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Double blind
Brain functioning
03 medical and health sciences
DOUBLE-BLIND
0302 clinical medicine
Depressed mood
Self-esteem
Medicine
Omega-3 Index
Depression (differential diagnoses)
PUBERTAL STATUS
Whole blood
media_common
Healthy youth
POLYUNSATURATED FATTY-ACIDS
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
STRESSFUL LIFE EVENTS
Original Contribution
Long-chain polyunsaturated fatty acid
MAJOR DEPRESSION
DOCOSAHEXAENOIC ACID
Eicosapentaenoic acid
SUBTHRESHOLD DEPRESSION
Docosahexaenoic acid
business
MENTAL-HEALTH
Clinical psychology
Zdroj: European Journal of Nutrition, 58, 4, pp. 1429-1439
European Journal of Nutrition
European Journal of Nutrition, 58(4), 1429-1439. Springer
van der Wurff, I S M, Von Schacky, C, Bergeland, T, Leontjevas, R, Zeegers, M, Kirschner, P A & de Groot, R H M 2019, ' Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education ', European Journal of Nutrition, vol. 58, no. 4, pp. 1429–1439 . https://doi.org/10.1007/s00394-018-1667-4
European Journal of Nutrition, 58, 1429-1439
European Journal of Nutrition, 58(4). D. Steinkopff-Verlag
ISSN: 1436-6207
Popis: PurposeDepression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE).MethodsBaseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5% were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE).ResultsScores indicative of depression (CES-D ≥ 16) were found in 29.4% of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [− 0.16; 95% credible interval (CI) − 0.28 to − 0.04; BF10 = 245], and substantial evidence for a weak positive association between ObA and self-esteem score (0.09; 95% CI, − 0.03 to 0.20; BF10 = 4). When all fatty acids were put in one model as predictors of CES-D or RSE, all of the 95% CI contained 0, i.e., no significant association.ConclusionNo evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5%. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.
Databáze: OpenAIRE
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