Adenovirus Is a Key Pathogen in Hemorrhagic Cystitis Associated with Bone Marrow Transplantation
| Autor: | Shu Tanikawa, Tadaichi Kitamura, Tetsuya Kurosu, Takashi Inoue, Kazuteru Ohashi, Yasusuke Onozawa, Qin Chen, Shinichiro Mori, Chizuko Sakashita, Huai-Ying Zheng, Hideki Akiyama, Hisashi Sakamaki |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Hemobilia viruses JC virus Urine Opportunistic Infections medicine.disease_cause Polymerase Chain Reaction Gastroenterology Virus Adenovirus Infections Human Internal medicine Cystitis medicine Humans Bone Marrow Transplantation business.industry Adenoviruses Human Papillomavirus Infections virus diseases Middle Aged medicine.disease JC Virus BK virus Tumor Virus Infections Infectious Diseases medicine.anatomical_structure BK Virus Immunology Female Viral disease Bone marrow business Complication Hemorrhagic cystitis |
| Zdroj: | Clinical Infectious Diseases. 32:1325-1330 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/319992 |
| Popis: | Late-onset hemorrhagic cystitis (HC) is a well-known complication of bone marrow transplantation (BMT) that is mainly attributed to infection with BK virus (BKV) and adenovirus (AdV). From 1986 through 1998, 282 patients underwent BMT, and 45 of them developed HC. Urine samples tested positive for AdV in 26 patients, of which 22 showed virus type 11. Among patients who underwent allogeneic BMT, logistic regression analysis revealed acute graft-versus-host disease (grade, > or = 2) to be the most significant predictive factor for HC (P < .0001). In addition, a total of 193 urine samples regularly obtained from 26 consecutive patients who underwent allogeneic BMT were examined for BKV, JC virus (JCV), and AdV by means of polymerase chain reaction. Of patients without HC, approximately 30% of the specimens tested positive for BKV (58 samples) and JCV (55 samples), whereas 5 (3%) tested positive for AdV. Of the 3 samples obtained from patients with HC, the numbers of positive results for BKV, JCV, and AdV were 3, 1, and 1, respectively; the numbers of positive results increased to 14 of 17, 9 of 17, and 10 of 17, respectively, when we added another 14 samples obtained from 14 patients with HC (P < .0001, P = .026, and P < .0001, respectively). In conclusion, there was significant correlation between AdV and HC in the patients we studied. |
| Databáze: | OpenAIRE |
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