Human and Mouse Homologues of the Drosophila melanogaster tweety (tty) Gene: A Novel Gene Family Encoding Predicted Transmembrane Proteins
| Autor: | Charles Claudianos, Makoto Kamei, Sumio Sugano, Grant R. Sutherland, Erica Woollatt, Hugh Campbell, Munetomo Hida, Yutaka Suzuki, Ian G. Young |
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| Rok vydání: | 2000 |
| Předmět: |
Male
DNA Complementary Sequence analysis Molecular Sequence Data Sequence alignment Hybrid Cells Mouse Protein Biology Mice Cricetinae Genetics Animals Humans Amino Acid Sequence Peptide sequence In Situ Hybridization Fluorescence Phylogeny Sequence Homology Amino Acid Chromosome Mapping Membrane Proteins Sequence Analysis DNA biology.organism_classification Chromosome Banding Drosophila melanogaster Membrane protein Insect Proteins Chromosomes Human Pair 19 Sequence Alignment Drosophila Protein Cation transport |
| Zdroj: | Genomics. 68:89-92 |
| ISSN: | 0888-7543 |
| Popis: | We have cloned cDNA for TTYH1, a human homologue of the Drosophila melanogaster tweety (tty) gene. The 450-residue predicted protein shows 27% amino acid sequence identity (51% similarity) to the Drosophila protein, which contains an additional C-terminal repetitive region. A second Drosophila homologue exhibits 42% identity (65% similarity) to the tty protein. Mouse (Ttyh1), macaque, and Caenorhabditis elegans homologues were also identified, and the complete coding sequence for the mouse gene was determined. The mouse protein is 91% identical to the human protein. Hydrophobicity analysis of the tty-related proteins indicates that they represent a new family of membrane proteins with five potential membrane-spanning regions. The yeast FTR1 and FTH1 iron transporter proteins and the mammalian neurotensin receptors 1 and 2 have a similar hydrophobicity profile, although there is no detectable sequence homology to the tty-related proteins. This suggests that the tweety-related proteins could be involved in transport of iron or other divalent cations or alternatively that they may be membrane-bound receptors. TTYH1 was mapped to chromosome 19q13.4 by FISH and by radiation hybrid mapping using the Stanford G3 panel. |
| Databáze: | OpenAIRE |
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