TRPC and TRPV Channels’ Role in Vascular Remodeling and Disease
| Autor: | Tarik Smani, Raquel del Toro, Isabel Galeano-Otero, Marta Martín-Bórnez |
|---|---|
| Přispěvatelé: | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gene isoform Vascular smooth muscle TRPC vascular remodeling Receptor potential TRPV Cation Channels Review 030204 cardiovascular system & hematology Vascular disease TRPV Catalysis lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences Transient receptor potential channel 0302 clinical medicine Animals Humans Medicine Vascular remodeling Vascular Diseases Physical and Theoretical Chemistry vascular tone lcsh:QH301-705.5 Molecular Biology Spectroscopy TRPC Cation Channels Vascular tone business.industry Organic Chemistry vascular disease General Medicine medicine.disease Personalized medicine Phenotype Computer Science Applications Cell biology 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Gene Expression Regulation Disease Progression business |
| Zdroj: | International Journal of Molecular Sciences idUS. Depósito de Investigación de la Universidad de Sevilla instname idUS: Depósito de Investigación de la Universidad de Sevilla Universidad de Sevilla (US) International Journal of Molecular Sciences, Vol 21, Iss 6125, p 6125 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in endothelial and vascular smooth muscle cells. Within the superfamily of TRP channels, different isoforms of TRPC (canonical) and TRPV (vanilloid) have emerged as important regulators of vascular tone and blood flow pressure. Additionally, several lines of evidence derived from animal models, and even from human subjects, highlighted the role of TRPC and TRPV in vascular remodeling and disease. Dysregulation in the function and/or expression of TRPC and TRPV isoforms likely regulates vascular smooth muscle cells switching from a contractile to a synthetic phenotype. This process contributes to the development and progression of vascular disorders, such as systemic and pulmonary arterial hypertension, atherosclerosis and restenosis. In this review, we provide an overview of the current knowledge on the implication of TRPC and TRPV in the physiological and pathological processes of some frequent vascular diseases. |
| Databáze: | OpenAIRE |
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