Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs
| Autor: | Marlene Drag, Diane Larsen, Bruce N. Kunkle, Theodore S. Chester |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Flea Veterinary medicine Administration Oral Physiology Naphthalenes Time Random Allocation Dogs Flea Infestations Afoxolaner Untreated control Oral administration Dog Animals Dog Diseases Ctenocephalides Early onset Antiparasitic Agents General Veterinary biology Felis Isoxazoles General Medicine biology.organism_classification veterinary(all) Ctenocephalides felis Female Parasitology Onset of action Curative efficacy Speed of kill |
| Zdroj: | Veterinary Parasitology. 201(3-4):204-206 |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/j.vetpar.2014.02.023 |
| Popis: | The speed of kill of afoxolaner against experimental infestations by Ctenocephalides felis was evaluated after oral administration of afoxolaner in a soft chew (NEXGARD®) at a dose to achieve 2.5mg/kg bodyweight. Forty beagles were allocated to two treatment groups. Dogs in Treatment Group 1 were untreated controls. Dogs in Treatment Group 2 were treated on Day-0 with afoxolaner, according to their pre-treatment bodyweight. All dogs were infested with approximately 100 C. felis on Day-1. Live fleas were counted upon removal at 5 time points after treatment (i.e., 2, 4, 8, 12 and 24h after treatment). For each time point, counts were performed on 4 dogs from each of the treated and the untreated groups. Early curative flea killing efficacy was evaluated with respect to the untreated control group. The afoxolaner treated group had significantly fewer fleas than the untreated control group at 8, 12, and 24h (p99.5% efficacy at 8, 12, and 24h after treatment demonstrating an early onset of action. |
| Databáze: | OpenAIRE |
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