Usefulness of Ct value in acute respiratory infections caused by respiratory syncytial virus A and B and influenza virus A (H1N1)pdm09, A (H3N2) and B
| Autor: | Jordi Reina, Carmen Morales, María Busquets, Cristina Norte |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Adolescent Coinfection Influenza A Virus H3N2 Subtype 030106 microbiology Infant Newborn Infant Respiratory Syncytial Virus Infections Viral Load Real-Time Polymerase Chain Reaction Body Fluids 03 medical and health sciences Influenza B virus 0302 clinical medicine Influenza A Virus H1N1 Subtype Child Preschool Acute Disease Influenza Human Humans RNA Viral 030212 general & internal medicine Prospective Studies Viremia Child |
| Zdroj: | Enfermedades infecciosas y microbiologia clinica (English ed.). 36(6) |
| ISSN: | 2529-993X |
| Popis: | Acute respiratory infections of viral cause are very frequent entities. The difficulty in evaluating the detection of a virus in these entities could be solved by determining the viral load.A prospective study on the mean Ct value (cycle threshold value) detected against RSV-A, RSV-B and influenza A (H1N1)pdm09, A (H3N2) and B viruses in patients of different origin and age was performed. Detection was performed using a commercial molecular amplification (RT-PCR) technique.Different mean Ct values were detected for each virus. In RSV infections, no differences were observed between those caused by RSV-A or RSV-B in children. Depending on the patient's age, the only statistical significance was observed in those included in the 0-4 month groups for RSV-A and this group and the 5-12 months group for RSV-B (higher values). A lower viral load was detected in adult patients than in paediatric patients. In influenza infections, no statistical significance was observed in the mean values detected in patients from the Red Centinela («sentinel network», a Spanish network of doctors aimed at research and surveillance of diseases), those diagnosed in the adult emergency room or in hospital admissions. In the adult patients admitted to the ICU, only a slightly lower mean value was observed in those infected with influenza A (H1N1)pdm09, but without statistical significance. There were no patients admitted to the ICU with influenza B infection.The detection of viral load could be a good tool for the evaluation, monitoring and prognosis of acute viral respiratory infections. With the exception of those caused by RSV, no significant differences were observed in influenza infections except in younger paediatric patients. |
| Databáze: | OpenAIRE |
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