Structural alterations of the superior temporal gyrus in schizophrenia: Detailed subregional differences
| Autor: | Kazuyuki Sawai, Hiroaki Okubo, Yukihisa Matsuda, Takamitsu Shimada, Toshiki Yasuyama, Kazutaka Ohi, Yusuke Nitta, Takashi Uehara, Kazuaki Oshima, Yasuhiro Kawasaki, Hiroaki Kihara |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male genetic structures Planum temporale Auditory cortex behavioral disciplines and activities Functional Laterality Temporal lobe 03 medical and health sciences Superior temporal gyrus Imaging Three-Dimensional 0302 clinical medicine Gyrus medicine Humans Gray Matter Gyrification Auditory Cortex Anatomy medicine.disease Magnetic Resonance Imaging Temporal Lobe 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Schizophrenia Case-Control Studies Laterality Female Psychology 030217 neurology & neurosurgery |
| Zdroj: | European Psychiatry. 35:25-31 |
| ISSN: | 1778-3585 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2016.02.002 |
| Popis: | BackgroundReduced gray matter volumes in the superior temporal gyrus (STG) have been reported in patients with schizophrenia. Such volumetric abnormalities might denote alterations in cortical thickness, surface area, local gyrification or all of these factors. The STG can be anatomically divided into five subregions using automatic parcellation in FreeSurfer: lateral aspect of the STG, anterior transverse temporal gyrus of Heschl gyrus (HG), planum polare (PP) of the STG, planum temporale (PT) of the STG and transverse temporal sulcus.MethodsWe acquired magnetic resonance imaging (MRI) 3T scans from 40 age- and sex-matched patients with schizophrenia and 40 healthy subjects, and the scans were automatically processed using FreeSurfer. General linear models were used to assess group differences in regional volumes and detailed thickness, surface area and local gyrification.ResultsAs expected, patients with schizophrenia had significantly smaller bilateral STG volumes than healthy subjects. Of the five subregions in the STG, patients with schizophrenia showed significantly and marginally reduced volumes in the lateral aspect of the STG and PT of the STG bilaterally compared with healthy subjects. The volumetric alteration in bilateral lateral STG was derived from both the cortical thickness and surface area but not local gyrification. There was no significant laterality of the alteration in the lateral STG between patients and controls and no correlation among the structures and clinical characteristics.ConclusionsThese findings suggest that of five anatomical subregions in the STG, the lateral STG is one of the most meaningful regions for brain pathophysiology in schizophrenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|