| Autor: |
Mandy Sanders, Chanaki Amaratunga, Frédéric Ariey, Matthew Berriman, Mallika Imwong, Rick M. Fairhurst, Tran Tinh Hien, Oliver O Koch, Issaka Zongo, Chris I. Newbold, Christina Hubbart, Pharath Lim, Lucas Amenga-Etego, Dushyanth Jyothi, Alistair Miles, Youry Se, Alfred Amambua-Ngwa, Christiane Dolecek, Jacob Almagro-Garcia, Susana Campino, David J. Conway, Christopher V. Plowe, Gareth Maslen, Gilean McVean, Abraham Hodgson, Sarah Auburn, Eleanor Drury, K.A. Rockett, David S. Saunders, Sokunthea Sreng, Maciej F. Boni, Julian C. Rayner, Delia Bethell, Pascal Ringwald, Abdoulaye A. Djimde, Jennifer M. Anderson, Magnus Manske, Char Meng Chuor, Daniel Alcock, Socheat Duong, Mark M. Fukuda, Bronwyn MacInnis, Cao Quang Thai, Seila Suon, Shannon Takala-Harrison, Chantap Lon, Dominic P. Kwiatkowski, John O'Brien, François Nosten, Olivo Miotto, Nicholas P. J. Day, Samuel O. Oyola, Nicholas J. White, Arjen M. Dondorp, Chea Nguon, Ogobara K. Doumbo, Valentin Ruano-Rubio, Victor Asoala, Chris C. A. Spencer, Xin-zhuan Su, Jean-Bosco Ouédraogo, Chris Gamble |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Nature genetics |
| ISSN: |
1546-1718
1061-4036 |
| Popis: |
We describe an analysis of genome variation in 825 Plasmodium falciparum samples from Asia and Africa that reveals an unusual pattern of parasite population structure at the epicentre of artemisinin resistance in western Cambodia. Within this relatively small geographical area we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and remarkably high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalogue of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in various transporter proteins and DNA mismatch repair proteins. These data provide a population genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist its elimination. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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