Cytomegalovirus disease in adult marrow transplant recipients receiving ganciclovir prophylaxis: a retrospective study

Autor: H, Maltezou, E, Whimbey, D, Abi-Said, D, Przepiorka, R, Champlin, J, Goodrich, H, Maltazou, R, Champlain
Rok vydání: 1999
Předmět:
Zdroj: Bone marrow transplantation. 24(6)
ISSN: 0268-3369
Popis: In a retrospective study, we compared the incidence and risk of mortality associated with CMV disease in adult allogeneic BMT and PBSC recipients who received ganciclovir prophylaxis three-times-per-week (78 patients) vs five-times-per-week (137 patients). Active CMV infection occurred in 28 (41%) and 26 (21%) in the three- vs five-times-per-week groups, respectively (P0.005). CMV disease developed in 11 (16%) and five (4%) patients who received ganciclovir prophylaxis in the three-times-per-week vs five-times-per-week groups (P0.004). The CMV-attributable mortality rate was 1.5% and 12% in the five- vsthree-times-per-week groups, respectively (P0.003). Risk factors for CMV disease, significant at the P0.05 level in the multivariate analysis, were ganciclovir prophylaxis at three-times-per-week, receiving a T cell-depleted (TCD) marrow, and tacrolimus as prophylaxis for GVHD. These data suggest that ganciclovir five-times-per-week significantly reduced the incidence and mortality of CMV disease in allogeneic BMT and PBSC recipients. However, ganciclovir five-times-per-week was less effective for the prevention of CMV disease in patients receiving TCD marrow or tacrolimus.
Databáze: OpenAIRE