Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Autor: Elena Crooks, Sophie M T Wehrens, Hans P. A. Van Dongen, Luigi Venetucci, Shobhan Gaddameedhi, Timothy M. Brown, John S. O’ Neill, Debra J. Skene, Andrew W. Trafford, Edward A. Hayter, Nichola J Barron, David A. Bechtold, Alessandra Stangherlin
Přispěvatelé: Hayter, Edward A [0000-0001-9996-7198], Wehrens, Sophie MT [0000-0001-7523-1514], Van Dongen, Hans PA [0000-0002-4678-2971], Stangherlin, Alessandra [0000-0001-7296-1183], O'Neill, John S [0000-0003-2204-6096], Trafford, Andrew W [0000-0002-2770-445X], Bechtold, David A [0000-0001-8676-8704], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Circadian clock
General Physics and Astronomy
030204 cardiovascular system & hematology
Arrhythmias
Sleep/physiology
Electrocardiography
Mice
0302 clinical medicine
Heart Rate
Medicine
Myocytes
Cardiac
Arrhythmias
Cardiac/genetics
Atrioventricular Node/metabolism
Sinoatrial Node
Multidisciplinary
medicine.diagnostic_test
ARNTL Transcription Factors
Autonomic Nervous System/physiology
Myocytes
Cardiac/metabolism
Middle Aged
Cardiovascular physiology
Circadian Rhythm
Sleep deprivation
Atrioventricular Node
cardiovascular system
Circadian Rhythm/physiology
Female
Electrical conduction system of the heart
medicine.symptom
Heart Rate/physiology
Cardiac function curve
Adult
Sinoatrial Node/metabolism
Science
ARNTL Transcription Factors/genetics
Mice
Transgenic
Autonomic Nervous System
Gene Expression Regulation/genetics
General Biochemistry
Genetics and Molecular Biology
Article
03 medical and health sciences
Circadian Clocks
Animals
Humans
Circadian rhythm
cardiovascular diseases
Author Correction
business.industry
Arrhythmias
Cardiac
General Chemistry
Circadian Clocks/physiology
Autonomic nervous system
Gene Expression Regulation
Circadian regulation
business
Sleep
Neuroscience
030217 neurology & neurosurgery
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Hayter, E A, Wehrens, S M T, Van Dongen, H P A, Stangherlin, A, Gaddameedhi, S, Crooks, E, Barron, N J, Venetucci, L A, Neill, J S O, Brown, T M, Skene, D J, Trafford, A W & Bechtold, D A 2021, ' Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia ', Nature Communications, vol. 12, no. 1, 2472 . https://doi.org/10.1038/s41467-021-22788-8
ISSN: 2041-1723
DOI: 10.1038/s41467-021-22788-8
Popis: Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial (SA) and atrioventricular (AV) node activity, and impose a time-of–day dependent susceptibility to ventricular arrhythmia. Critically, the balance of circadian inputs from the autonomic nervous system and cardiomyocyte clock to the SA and AV nodes differ, and this renders the cardiac conduction system sensitive to decoupling during abrupt shifts in behavioural routine and sleep-wake timing. Our findings reveal a functional segregation of circadian control across the heart’s conduction system and inherent susceptibility to arrhythmia.
Cardiac function fluctuates greatly across the day and night, but this is not simply a consequence of our changing behaviour. The authors highlight the role of the body’s circadian clock in regulating the heart electrical activity, including a time-of-day dependent susceptibility to cardiac arrhythmias.
Databáze: OpenAIRE
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