Magnetic resonance imaging-guided and targeted theranostics of colorectal cancer
| Autor: | Yongbing Sun, Tao Han, Yanan Li, Hui Zhang, Feifei An, Jingqi Xin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Colorectal cancer medicine.medical_treatment targeted theranostics colorectal cancer Review Ferric Compounds lcsh:RC254-282 Theranostic Nanomedicine Targeted therapy 03 medical and health sciences Treatment status High morbidity Drug Delivery Systems 0302 clinical medicine Internal medicine medicine Humans magnetic resonance imaging Magnetite Nanoparticles 030304 developmental biology 0303 health sciences medicine.diagnostic_test business.industry Cancer Magnetic resonance imaging lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 030220 oncology & carcinogenesis Colorectal Neoplasms multimodal diagnosis business carcinogenesis |
| Zdroj: | Cancer Biology & Medicine, Vol 17, Iss 2, Pp 307-327 (2020) Cancer Biology & Medicine |
| ISSN: | 2095-3941 |
| DOI: | 10.20892/j.issn.2095-3941.2020.0072 |
| Popis: | Colorectal cancer (CRC) is the most common gastrointestinal tract cancer worldwide and is associated with high morbidity andmortality. The development of nanosized drug delivery systems has provided a new direction in CRC treatment. Among thesesystems, magnetic nanoparticle (MNP)-based multifunctional platforms provide a novel strategy for magnetic resonance imaging(MRI)-related cancer theranostics. At the beginning of this original review, the carcinogenesis and treatment status of CRC aresummarized. Then, diversified preparation and functionalization methods of MNPs are systematically analyzed, followed by MRIinvolvedtheranostic strategies. The latest progress in MRI-mediated multimode diagnosis and image-guided targeted therapy inCRC management is the main focus. Finally, the major challenges in promoting MRI-induced precise theranostics of CRC in clinicalpractice are discussed. Cite this article as: Li Y, Xin J, Sun Y, Han T, Zhang H, An F. Magnetic resonanceimaging-guided and targeted theranostics of colorectal cancer. Cancer BiolMed. 2020; 17: 307-327. doi: 10.20892/j.issn.2095-3941.2020.0072 |
| Databáze: | OpenAIRE |
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