Effect of HLA mismatches on the outcome of hematopoietic transplants
| Autor: | John A. Hansen, Ann E. Woolfrey, Paul J. Martin, Effie W. Petersdorf, Claudio Anasetti, Eric Mickelson |
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| Rok vydání: | 1999 |
| Předmět: |
Graft Rejection
business.industry Histocompatibility Testing medicine.medical_treatment Graft Survival Immunology Hematopoietic Stem Cell Transplantation Disease Human leukocyte antigen Hematopoietic stem cell transplantation Hematologic Diseases Transplantation Humans Immunology and Allergy Medicine Organ donation Allele business Genotyping |
| Zdroj: | Current Opinion in Immunology. 11:521-526 |
| ISSN: | 0952-7915 |
| DOI: | 10.1016/s0952-7915(99)00016-3 |
| Popis: | Hematopoietic cell transplantation from unrelated volunteer donors for the treatment of hematological malignancy can be optimized by complete and precise matching for HLA class I and II alleles between the donor and recipient. Survival is improved when the donor and recipient are matched for HLA-A, -B, -C, -DRB, -DQB1 and -DPB1 alleles. The risks of clinically severe graft-versus-host disease, graft failure and mortality are increased in the presence of multilocus mismatching. These findings demonstrate that HLA allelic differences are biologically relevant in human transplantation. |
| Databáze: | OpenAIRE |
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