Deficits in LTP and recognition memory in the genetically hypertensive rat are associated with decreased expression of neurotrophic factors and their receptors in the dentate gyrus
| Autor: | Amy Hennigan, Jennifer Rouine, Áine M. Kelly, Charlotte K. Callaghan, John Kealy |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Blotting Western Long-Term Potentiation Hippocampus Enzyme-Linked Immunosorbent Assay Tropomyosin receptor kinase B Neurotrophin-3 Behavioral Neuroscience Neurotrophin 3 Memory Internal medicine medicine Animals Receptor trkB Receptor trkC Nerve Growth Factors Rats Wistar Receptor trkA Brain-derived neurotrophic factor Analysis of Variance biology Dentate gyrus Brain-Derived Neurotrophic Factor Long-term potentiation Rats Disease Models Animal Endocrinology nervous system Trk receptor Dentate Gyrus Hypertension biology.protein Neuroscience Neurotrophin |
| Zdroj: | Behavioural brain research. 197(2) |
| ISSN: | 1872-7549 |
| Popis: | We have previously reported that a genetically hypertensive strain of Wistar rat (GH), is deficient in nerve growth factor (NGF) and Trk receptors in dentate gyrus and that these deficits are accompanied by impaired expression of long-term potentiation (LTP) in perforant path-granule cell synapses. Here we confirm this deficit in LTP and report that this strain of rat also displays impairments in long-term recognition memory when compared with normotensive controls. Further analysis of neurotrophin expression in dentate gyrus confirmed the previously-reported deficit in NGF and revealed a decrease in expression of brain-derived neurotrophic factor (BDNF), but not neurotrophin 3 (NT3) or neurotrophin 4 (NT4), in GH rats. These alterations in ligand expression were accompanied by changes in Trk receptor expression; specifically, a decrease in expression of TrkA and TrkB, but not TrkC, in the dentate gyrus of GH, compared with normotensive, rats. We conclude that the impairments in LTP and learning and memory observed in the GH strain are associated with aberrant expression of specific neurotrophic factors and their receptors in the dentate gyrus, adding weight to the evidence indicating a role for these proteins in several forms of synaptic plasticity. |
| Databáze: | OpenAIRE |
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