Pregnancy outcome and cord blood cotinine level: A cross-sectional comparative study between secondhand smokers and non-secondhand smokers
| Autor: | Methil Kannan Kutty, M.N. Norizal, B. Muadz, Nurhuda Ismail, Bahiyah Abdullah, Noor Kaslina Mohd Kornain |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Birth weight Umbilical cord Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pregnancy medicine Humans Caesarean section 030212 general & internal medicine Cotinine 030219 obstetrics & reproductive medicine Obstetrics business.industry Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Fetal Blood medicine.disease Cross-Sectional Studies medicine.anatomical_structure Reproductive Medicine chemistry Cord blood Female Tobacco Smoke Pollution Apgar score business Body mass index |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 214:86-90 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2017.05.002 |
| Popis: | Objective To compare the pregnancy outcome and cord blood cotinine levels between secondhand smokers and non-secondhand smokers. Study design This was a cross-sectional comparative study in a Malaysian tertiary obstetric hospital involving 200 non-smoking pregnant women at term, of whom 100 were secondhand smokers and 100 were non-secondhand smokers. Those with multiple pregnancies, with a body mass index (BMI) of more than 30 kg/m 2 or who delivered by Caesarean section were excluded. The participants’ basic demographic details, delivery details, neonatal outcome and placental weight were recorded. Umbilical cord blood samples were obtained, and cord blood cotinine levels were measured with a Cotinine ELISA kit. The primary outcomes were baby’s birth weight, length, and head circumference, Apgar score at 5 min and placental weight. The secondary outcome was difference in cord blood cotinine levels between the two groups and the correlation of these differences with the neonatal outcome. Results The secondhand smoker group had significantly lower baby weight (2.94 ± 0.31 kg vs 3.05 ± 0.40 kg), head circumference (30.87 ± 2.35 cm vs 37.13 ± 2.36 cm), length (46.58 ± 1.95 cm vs 51.53 ± 2.05 cm) and placental weight (520 ± 73.5 g vs 596 ± 61.3 g) and significantly higher cord blood cotinine levels (16.35 ± 12.84 ng/mL vs 0.56 ± 0.22 ng/mL). Cord blood cotinine levels had significant negative correlations with placental weight (r = −0.461), baby’s weight (r = −0.297), baby’s head circumference (r = −0.501) and baby’s length (r = −0.374). Conclusion Secondhand smoke increases the incidence of adverse pregnancy outcomes (newborns’anthropometric measurements and placental weight) and causes higher cord blood cotinine levels. |
| Databáze: | OpenAIRE |
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