Expert Perspectives On Clinical Challenges: Expert Perspectives: Challenges in Scleroderma

Autor: Robert W. Simms
Rok vydání: 2020
Předmět:
Endothelin Receptor Antagonists
Indoles
Vasodilator Agents
Angiotensin-Converting Enzyme Inhibitors
Scleroderma
0302 clinical medicine
Immunology and Allergy
Medicine
Renal Insufficiency
030212 general & internal medicine
Plasma Exchange
medicine.diagnostic_test
Complement C4
Sclerodactyly
Complement C3
Microangiopathic hemolytic anemia
FINGER SWELLING
Calcium Channel Blockers
medicine.anatomical_structure
Antibodies
Antinuclear

Antirheumatic Agents
Hypertension
medicine.symptom
medicine.medical_specialty
Immunology
Physical examination
Antibodies
Monoclonal
Humanized

Transplantation
Autologous

Angiotensin Receptor Antagonists
03 medical and health sciences
Rheumatology
Scleroderma
Limited

Humans
Cyclophosphamide
Protein Kinase Inhibitors
Adrenergic alpha-Antagonists
Antihypertensive Agents
030203 arthritis & rheumatology
Lung
business.industry
RNA Polymerase III
Raynaud Disease
medicine.disease
Dermatology
Complement Inactivating Agents
Blood pressure
Scleroderma
Diffuse

Crackles
Lung Diseases
Interstitial

Tomography
X-Ray Computed

business
Stem Cell Transplantation
Zdroj: Arthritis & Rheumatology. 72:1415-1426
ISSN: 2326-5205
2326-5191
DOI: 10.1002/art.41406
Popis: You are consulted to evaluate a 56-year-old woman with known Raynaud's phenomenon, finger swelling of several; months' duration, and new hypertension with a blood pressure of 160/100 mm/Hg. She also reports progressive shortness of breath. Physical examination reveals telangiectasias, sclerodactyly, and proximal skin sclerosis (thick shiny skin on the chest and upper arms), and bibasilar crackles are found on chest examination. Laboratory tests reveal evidence of microangiopathic hemolytic anemia, thrombocytopenia, and elevation of the serum creatinine level (previously normal), and chest computed tomography shows evidence of ground-glass opacification in both lower lung fields.
Databáze: OpenAIRE