Double Linear Gradient Biointerfaces for Determining Two-Parameter Dependent Stem Cell Behavior
| Autor: | Patrick van Rijn, Qihui Zhou, Aneta M. Schaap-Oziemlak, Torben A. B. van der Boon, Theo G. van Kooten, Philipp T. Kühn |
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| Přispěvatelé: | Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Nanotechnology and Biophysics in Medicine (NANOBIOMED) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
gradients OSTEOGENIC DIFFERENTIATION animal structures Materials science FATE Energy Engineering and Power Technology wettability Nanotechnology Biointerface macromolecular substances 02 engineering and technology ADHESION 010402 general chemistry 01 natural sciences Biomaterials SELF-ASSEMBLED MONOLAYERS SUBSTRATE stem cells Monolayer Materials Chemistry medicine Composite material biointerfaces Renewable Energy Sustainability and the Environment GUIDANCE MARROW STROMAL CELLS POLYMER SURFACES technology industry and agriculture Stiffness Substrate (chemistry) Self-assembled monolayer STIFFNESS Adhesion Decoupling (cosmology) equipment and supplies 021001 nanoscience & nanotechnology 0104 chemical sciences INTERFACE Wetting medicine.symptom 0210 nano-technology |
| Zdroj: | Chemnanomat, 2(5), 407-413. Wiley |
| ISSN: | 2199-692X |
| DOI: | 10.1002/cnma.201600028 |
| Popis: | Two-parameter contributions of stiffness and wettability display altered behavior of hBM-MSCs as compared to solely investigating the wettability of the biointerface with a homogenous stiffness. The importance of double parameter influence is identified by using newly developed double linear wettability-stiffness gradients. The interfaces show that substrate stiffness can influence cell adhesion and spreading both positively and negatively in combination with wettability. This effect is validated by decoupling the stiffness gradient using a wettability gradient composed of a monolayer on glass ensuring a homogenous stiffness. |
| Databáze: | OpenAIRE |
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