Clinical observations and risk factors for tinnitus in a Sicilian cohort
| Autor: | Mariana Mucia, Federico Sireci, Roberta Costanzo, Enrico Martines, Fulvio Plescia, Francesco Martines, Emanuele Cannizzaro, Pietro Salvago |
|---|---|
| Přispěvatelé: | Martines, F., Sireci, F., Cannizzaro, E., Costanzo, R., Martines, E., Mucia, M., Plescia, F., Salvago, P. |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Tinnitus Hearing loss Risk factors Multi-frequency audiometry TEOAE Adolescent Hearing loss Otoacoustic Emissions Spontaneous Audiology Multi-frequency audiometry TEOAE Risk Assessment Tinnitus Young Adult Audiometry Risk Factors otorhinolaryngologic diseases medicine Prevalence Humans Sicily Aged Aged 80 and over Univariate analysis medicine.diagnostic_test business.industry Settore MED/44 - Medicina Del Lavoro General Medicine Middle Aged medicine.disease Comorbidity Settore MED/32 - Audiologia Settore MED/31 - Otorinolaringoiatria Otorhinolaryngology Cohort Tinnitus Hearing loss Risk factor Female medicine.symptom business Lipid profile Body mass index Follow-Up Studies |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 272(10) |
| ISSN: | 1434-4726 |
| Popis: | The aims of this study were to determine the distribution of risk factors associated with tinnitus analysing their role in the development of tinnitus and the effects of their interaction; to evidence the importance of a suitable and adequate clinical and audiologic assessment to avoid those modifiable risk factors responsible for cochlear dysfunction and tinnitus onset. 46 subjects with tinnitus and 74 controls were studied according to: age, sex, Body Mass Index (BMI), neck circumference, tobacco smoking, feeling fatigue or headache, self reporting snoring, hypertension, diabetes, coronary heart disease, and/or hyperlipidemia, and laboratory finding as lipid profile and levels of reactive oxygen metabolites (d-ROM). Audiological assessment was performed by multi-frequency audiometry (PTA0.5–16 kHz) and transient-evoked otoacoustic emissions (TEOAE diagnostic). Univariate analysis was performed to examine the association between determinants and occurrence of tinnitus; Mantel–Haenszel test (G.or) was used to investigate the joint effect of determinants on tinnitus. Tinnitus was more frequent among males with age >50 years; BMI >30 kg/m2, neck circumference >40 cm, headache, hypertension, hypercholesterolemia resulted significant risk factors for tinnitus (P < 0.0001). Tinnitus group had more comorbidity (P < 0.0001) and worse audiometric thresholds (60.87 Vs 21.62 % hearing loss; P < 0.0001) with respect to control group. The interaction between hypertension–BMI ≥ 30 kg/m2 (G.or = 8.45) and smoking–hypercholesterolemia (G.or = 5.08) increases the risk of tinnitus (P < 0.0001). Our results underline that several factors either individually or jointly contribute to tinnitus onset; a comprehensive knowledge about tinnitus risk factors and associated clinical conditions could contribute to minimizing this disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink