Serum concentration of asprosin in new-onset type 2 diabetes

Autor:	Hafez Heydari, Shakiba Naiemian, Mehdi Zarei, Mohsen Naeemipour, Mohammad Reza Behroozikhah, Moslem Lari Najafi, Mohammad Miri, Ali Gohari
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Asprosin Adipokine 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Internal Medicine medicine Risk factor lcsh:RC620-627 business.industry Insulin Research Type 2 Diabetes Mellitus nutritional and metabolic diseases Odds ratio medicine.disease lcsh:Nutritional diseases. Deficiency diseases 030104 developmental biology Endocrinology business
Zdroj:	Diabetology & Metabolic Syndrome, Vol 12, Iss 1, Pp 1-8 (2020) Diabetology & Metabolic Syndrome
ISSN:	1758-5996
DOI:	10.1186/s13098-020-00564-w
Popis:	Background Asprosin, a newly identified adipokine, is pathologically increased in individuals with insulin resistance. However, the available evidence on the association of asprosin and type 2 diabetes mellitus (T2DM) status is still scarce. Therefore, this study aimed to determine the relationship between serum concentrations of asprosin and T2DM status. Methods This observational study was performed based on 194 adults (97 newly diagnosed T2DM and 97 healthy individuals). Anthropometric and biochemical variables were determined in all participants. Serum concentrations of asprosin were measured using enzyme-linked immunosorbent assay (ELISA). Results In patients with T2DM, the serum concentrations of asprosin were significantly higher than the healthy controls (4.18 [IQR: 4.4] vs. 3.5 [IQR: 1.85], P Conclusion Our findings indicated that serum concentrations of asprosin are increased in patients with T2DM. Also, asprosin is correlated with insulin resistance and TC/HDL-C ratio (atherosclerotic risk factor of cardiovascular diseases) in patients with T2DM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9369cc16a8067045edaa9c293a27e70 http://link.springer.com/article/10.1186/s13098-020-00564-w Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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