Hyperinsulinemia and Insulin Receptor Gene Mutation in Nonobese Healthy Subjects in Japan
| Autor: | Takehiko Watanabe, Junji Kozawa, Hiromi Iwahashi, Akihisa Imagawa, Iichiro Shimomura, Yohei Kuroda, Ryuya Iwamoto, Yuya Yamada, Shingo Fujita, Kenji Fukui |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Diabetes Pancreatic and Gastrointestinal Hormones Fasting hyperinsulinemia Endocrinology Diabetes and Metabolism Nonsense mutation 030209 endocrinology & metabolism Context (language use) 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus medicine Hyperinsulinemia insulin receptor gene Clinical Research Articles business.industry nonobese medicine.disease 030104 developmental biology Endocrinology glucose intolerance healthy subjects hyperinsulinemia Donohue syndrome business Body mass index |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| DOI: | 10.1210/js.2017-00332 |
| Popis: | Context: Hyperinsulinemia is often observed in obese people, owing to their insulin resistance accompanied by visceral fat accumulation, but the frequency of hyperinsulinemia in nonobese people is not well known. Mutations in the insulin receptor gene are known to cause insulin resistance and hyperinsulinemia in type A insulin resistance syndrome, Rabson-Mendenhall syndrome, and Donohue syndrome. However, insulin receptor gene abnormalities have not been investigated in asymptomatic hyperinsulinemic subjects. Purpose: The aim of the current study was to investigate the prevalence of hyperinsulinemia in nonobese Japanese subjects and to examine the involvement of insulin receptor gene mutations. Methods: We enrolled 11,046 subjects who received health checkups. From these, we extracted nonobese subjects (body mass index G (p.Y702X) and c.2779-2780 GC>A]. The prevalence of insulin receptor gene mutations was 18.2% (2/11). Conclusions: To our knowledge, this is the first report of the prevalence of hyperinsulinemia in nonobese healthy subjects. We identified two novel mutations in the insulin receptor gene. These findings indicate that mutations in the insulin receptor gene may be related to fasting hyperinsulinemia, and insulin receptor gene screening may be useful for determining the cause of unexplained hyperinsulinemia. In nonobese healthy subjects, the prevalence of hyperinsulinemia without apparent diabetes is 0.4%. The prevalence of insulin receptor gene mutations in 11 subjects with hyperinsulinemia is 18.2%. |
| Databáze: | OpenAIRE |
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