A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori
| Autor: | Satoshi Goshi, Hui-Min Zhang, Hiroyuki Matsumaru, Seiichi Kojio, Tatsuki Ohara, Nobuhiro Iwakura, Nanako Tsutsui, T. Noriko Wakisaka-Saito, Ikue Taneike, Tatsuo Yamamoto |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Rabeprazole
Lansoprazole Motility Microbial Sensitivity Tests Sulfides medicine.disease_cause 2-Pyridinylmethylsulfinylbenzimidazoles Microbiology medicine Humans Pharmacology (medical) Mechanisms of Action: Physiological Effects Pharmacology biology Helicobacter pylori Vibrio parahaemolyticus Temperature Proton Pump Inhibitors Hydrogen-Ion Concentration biology.organism_classification bacterial infections and mycoses Anti-Ulcer Agents Infectious Diseases Vibrio cholerae Salmonella enterica Benzimidazoles Bacteria Cell Division Omeprazole medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 44(11) |
| ISSN: | 0066-4804 |
| Popis: | The motility of Helicobacter pylori was maximum at 37°C and at pH 6. A newly developed proton pump inhibitor, rabeprazole (RPZ), and its thioether derivative (RPZ-TH) markedly inhibited the motility of H. pylori . The concentrations of the drug necessary to inhibit 50% of the motility were 0.25, 16, 16, and >64 μg/ml for RPZ-TH, RPZ, lansoprazole, and omeprazole, respectively. No such inhibitory effects were observed with H 2 blockers or anti- H. pylori agents. The motilities of Campylobacter jejuni and C. coli —but not those of Vibrio cholerae O1 and O139, Vibrio parahaemolyticus , Salmonella enterica serovar Typhimurium, and Proteus mirabilis —were also inhibited. Prolonged incubation with RPZ or RPZ-TH inhibited bacterial growth of only H. pylori , except for a turbid colony mutant. The results indicate that RPZ and RPZ-TH have a characteristic inhibitory effect against the motility of H. pylori (spiral-shaped bacteria), which is distinguished from that against bacterial growth. |
| Databáze: | OpenAIRE |
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