Saquinavir, nelfinavir and M8 pharmacokinetics following combined saquinavir, ritonavir and nelfinavir administration
| Autor: | Mark Becker, Antje Breske, Christian Herzmann, Guido Kruse, Hubert Schulbin, Michael Kurowski, Hartmut Stocker, Keikawus Arastéh, Jutta Steinmüller, Marcel Berger, Andrew Hill |
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| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Adult Male Anti-HIV Agents viruses HIV Infections Pharmacology Drug Administration Schedule Pharmacokinetics immune system diseases medicine Humans Pharmacology (medical) Protease inhibitor (pharmacology) Drug Interactions Saquinavir Cross-Over Studies Nelfinavir Ritonavir business.industry virus diseases biochemical phenomena metabolism and nutrition Drug interaction Middle Aged Crossover study Regimen Infectious Diseases Drug Therapy Combination business medicine.drug |
| Zdroj: | The Journal of antimicrobial chemotherapy. 59(3) |
| ISSN: | 0305-7453 |
| Popis: | Objectives: This study evaluated the steady-state pharmacokinetic interaction between ritonavir-boosted saquinavir and nelfinavir. Methods: Open label, multiple-dose, two parallel-groups, single crossover study conducted in 24 HIV-infected patients (12 in each group). Patients in the nelfinavir group added saquinavir/ritonavir, 1000/100 mg twice daily to their ongoing stable treatment regimen consisting of nelfinavir, 1250 mg twice daily and two nucleoside reverse transcriptase inhibitors (NRTIs). Patients in the saquinavir group added nelfinavir, 1250 mg twice daily to their ongoing stable treatment regimen consisting of saquinavir/ritonavir, 1000/100 mg twice daily and two NRTIs. Pharmacokinetic assessments were performed before and 7 days after the start of combined treatment with nelfinavir/saquinavir/ritonavir. Blood samples were collected before and 1, 2, 3, 4, 6, 8, 10 and 12 h after dosing for measurement of nelfinavir, the nelfinavir metabolite M8 and saquinavir using liquid chromatography tandem mass spectrometry (LC-MS/MS). Results: The addition of saquinavir/ritonavir to the nelfinavir-containing regimen resulted in significant increases in the M8 pharmacokinetic parameters AUCO-12, C max and C 12 ; geometric mean ratios (90% confidence intervals) of 2.25 ng-h/mL (1.47-3.44), 1.74 ng/mL (1.25-2.40) and 4.21 ng/mL (2.10-8.47), respectively. The intra-individual changes in nelfinavir and saquinavir concentrations were highly variable. Statistical analysis could not discard a relevant interaction but includes the possibility that some parameters may be halved, others more than doubled. At the same time the analysis failed to show any directed change. Conclusions: The co-administration of nelfinavir and saquinavir/ritonavir leads to unpredictable changes in concentrations of both drugs. It is unclear whether the increased concentrations of M8 are associated with a clinical benefit. |
| Databáze: | OpenAIRE |
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