The calcium sensing receptor: from calcium sensing to signaling
| Autor: | Cassandra Lynn Miller, Chen Zhang, Edward M. Brown, Jenny J. Yang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Biology Ligands General Biochemistry Genetics and Molecular Biology Environmental Science(all) Internal medicine medicine Extracellular Homeostasis Humans Hypercalciuria Receptor General Environmental Science Familial hypocalciuric hypercalcemia Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) medicine.disease Endocrinology Hypercalcemia Calcium Signal transduction Calcium-sensing receptor General Agricultural and Biological Sciences Receptors Calcium-Sensing Intracellular Signal Transduction |
| Zdroj: | Science China. Life sciences. 58(1) |
| ISSN: | 1869-1889 |
| Popis: | The Ca(2+)-sensing receptor (the CaSR), a G-protein-coupled receptor, regulates Ca(2+) homeostasis in the body by monitoring extracellular levels of Ca(2+) ([Ca(2+)]o) and responding to a diverse array of stimuli. Mutations in the Ca(2+)-sensing receptor result in hypercalcemic or hypocalcemic disorders, such as familial hypocalciuric hypercalcemia, neonatal severe primary hyperparathyroidism, and autosomal dominant hypocalcemic hypercalciuria. Compelling evidence suggests that the CaSR plays multiple roles extending well beyond not only regulating the level of extracellular Ca(2+) in the human body, but also controlling a diverse range of biological processes. In this review, we focus on the structural biology of the CaSR, the ligand interaction sites as well as their relevance to the disease associated mutations. This systematic summary will provide a comprehensive exploration of how the CaSR integrates extracellular Ca(2+) into intracellular Ca(2+) signaling. |
| Databáze: | OpenAIRE |
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