Nonrandom cytogenetic changes in New Zealand patients with acute myeloid leukemia
| Autor: | Christine M. Morris, Lynette M. Giles, G.J. Fraser, D. C. Heaton, Peter H. Fitzgerald, M. E. J. Beard, J. W. Hamer |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Myeloid Acute myeloblastic leukemia Biology Trisomy 8 Gastroenterology Bone Marrow hemic and lymphatic diseases Internal medicine Genetics medicine Humans Molecular Biology Chromosome Aberrations Myeloid leukemia Karyotype Middle Aged medicine.disease Chromosome Banding Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Karyotyping Leukemia Monocytic Acute Acute myelomonocytic leukemia Immunology Female Leukemia Erythroblastic Acute Trisomy New Zealand |
| Zdroj: | Cancer Genetics and Cytogenetics. 8:51-66 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(83)90064-x |
| Popis: | Bone marrow clones with abnormal chromosomes were observed in 56% of 66 patients with forms of acute myeloid leukemia [French-American-British (FAB) M1-M6]. Acute myeloblastic leukemia (AML, M1 and M2) was the most common form, and 65% of these patients showed chromosomal abnormalities compared with 41% of patients with acute myelomonocytic leukemia (AMMoL, M4). The recognized nonrandom chromosomal abnormalities found were trisomy 8, monosomy 5 or 7, trisomy 1q, t(6;9), t(8;21), t(15;17), and abnormalities in 17q. There was also a strong involvement of chromosome No. 11: Abnormalities were found in eight patients when their leukemia was diagnosed and in a further three patients during the course of karyotypic evolution. Six of these patients had AMMoL or AMoL. Complex or multiple clones were found in 37% of AML patients at diagnosis. Our AML patients had a reduced frequency of abnormalities in chromosome No. 5 or 7 and an increased frequency of abnormalities in chromosome No. 8 compared with studies reported in other countries (p = 0.01). This difference suggests that in New Zealand AML might be caused by factors different from those operating in more industrialized centers. |
| Databáze: | OpenAIRE |
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