Detection of circulating DNA in plasma of patients with pulmonary embolism by counterimmunoelectrophoresis
| Autor: | Erminio Longhini, Riccardo Asero, P. Cherubini, Luigi Marazzini, Piersandro Riboldi, Invernizzi F, Miriam Pacetti |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pathology Counterimmunoelectrophoresis Specific test medicine.diagnostic_test business.industry Plasma dna Immunoelectrophoresis DNA medicine.disease Gastroenterology Pulmonary embolism Internal medicine medicine Circulating DNA Humans business Pulmonary Embolism |
| Zdroj: | Respiration; international review of thoracic diseases. 45(1) |
| ISSN: | 0025-7931 |
| Popis: | In order to confirm the usefulness of free plasma DNA detection in the diagnosis of pulmonary embolism (PE), we have studied 16 patients with PE, 33 with various diseases, and 13 normal subjects. Free plasma DNA was detectable in 15 of 16 patients with PE (94%) and in 3 control patients, but never in plasma from normal subjects. In most cases, DNA was detectable until the 10th day after PE. In conclusion, counterimmunoelectrophoresis is a rapid, inexpensive and specific test which may be used as an exclusion test in the detection of patients suspected of having PE, who will have to undergo more extensive evaluation. |
| Databáze: | OpenAIRE |
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