High frequency of silent brain infarcts associated with cognitive deficits in an economically disadvantaged population

Autor: Marcia Scazufca, Tania Correa de Toledo Ferraz Alves, Geraldo F. Busatto, Claudia da Costa Leite, Paula Squarzoni, Fábio L.S. Duran, Paulo Rossi Menezes, Jaqueline H. Tamashiro-Duran, Paulo A. Lotufo, Mauricio Wajngarten
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Brain Infarction
Male
medicine.medical_specialty
Neuropsychological Tests
030204 cardiovascular system & hematology
Audiology
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Cognition
Educational Level
Reference Values
Risk Factors
Prevalence
medicine
Humans
Dementia
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
Psychiatry
Aged
Intelligence Tests
Psychiatric Status Rating Scales
lcsh:R5-920
Analysis of Variance
medicine.diagnostic_test
Intelligence quotient
Framingham Coronary Heart Disease Risk
Age Factors
Magnetic resonance imaging
General Medicine
Clinical Science
medicine.disease
Magnetic Resonance Imaging
Confidence interval
Disadvantaged
Cognitive test
Ageing
Silent Brain Infarction
Socioeconomic Factors
Asymptomatic Diseases
Female
lcsh:Medicine (General)
Psychology
Brazil
030217 neurology & neurosurgery
Zdroj: Clinics, Volume: 72, Issue: 8, Pages: 474-480, Published: AUG 2017
Clinics
Clinics; v. 72 n. 8 (2017); 474-480
Clinics; Vol. 72 Núm. 8 (2017); 474-480
Clinics; Vol. 72 No. 8 (2017); 474-480
Universidade de São Paulo (USP)
instacron:USP
Clinics, Vol 72, Iss 8, Pp 474-480
ISSN: 1980-5322
1807-5932
Popis: OBJECTIVE: Using magnetic resonance imaging, we aimed to assess the presence of silent brain vascular lesions in a sample of apparently healthy elderly individuals who were recruited from an economically disadvantaged urban region (São Paulo, Brazil). We also wished to investigate whether the findings were associated with worse cognitive performance. METHODS: A sample of 250 elderly subjects (66-75 years) without dementia or neuropsychiatric disorders were recruited from predefined census sectors of an economically disadvantaged area of Sao Paulo and received structural magnetic resonance imaging scans and cognitive testing. A high proportion of individuals had very low levels of education (4 years or less, n=185; 21 with no formal education). RESULTS: The prevalence of at least one silent vascular-related cortical or subcortical lesion was 22.8% (95% confidence interval, 17.7-28.5), and the basal ganglia was the most frequently affected site (63.14% of cases). The subgroup with brain infarcts presented significantly lower levels of education than the subgroup with no brain lesions as well as significantly worse current performance in cognitive test domains, including memory and attention (p
Databáze: OpenAIRE
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