Relationship Between Serum IGF-1 and BMI Differs by Age
| Autor: | Joseph M. Zmuda, Candace M. Kammerer, Allison L. Kuipers, Rehab A Sherlala, Svetlana V. Ukraintseva, Mary K. Wojczynski, Mary F. Feitosa, Jonas Mengel-From, Ryan L. Minster |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Aging National Health and Nutrition Examination Survey THE JOURNAL OF GERONTOLOGY: Medical Sciences 030204 cardiovascular system & hematology Body Mass Index Correlation 03 medical and health sciences 0302 clinical medicine Age groups Humans Medicine Age-related pattern Longitudinal Studies Insulin-Like Growth Factor I Aged Aged 80 and over National health business.industry Age Factors Regression analysis Middle Aged 030104 developmental biology Quartile Female Disease Susceptibility Geriatrics and Gerontology business Body mass index Age-related diseases Demography |
| Zdroj: | J Gerontol A Biol Sci Med Sci Sherlala, R A, Kammerer, C M, Kuiper, A L, Wojczynski, M K, Ukraintseva, S V, Feitosa, M F, Mengel-From, J, Zmuda, J M & Minster, R L 2021, ' Relationship between Serum IGF-1 and BMI differs by Age ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 76, no. 7, pp. 1303–1308 . https://doi.org/10.1093/gerona/glaa282 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glaa282 |
| Popis: | Background Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies. Methods Using data on 4241 participants (aged 24–110) from the Long Life Family Study, we investigated the relationship between IGF-1 and BMI by age groups using regression analysis. Results When stratified by age quartile, the relationship between IGF-1 and BMI varied: in the first quartile (Q1, 20–58 years) the relationship was negative (β = −0.2, p = .002); in Q2 (58–66 years) and Q3 (67–86 years) the relationship was negative (β = −0.07, β = −0.01, respectively) but nonsignificant; and in Q4 (87–110 years) the relationship was positive (β = 0.31, p = .0002). This pattern did not differ by sex. We observed a similar age-related pattern between IGF-1 and BMI among participants in the third National Health and Nutritional Examination Survey. Conclusions Our results that the relationship between IGF-1 and BMI differs by age may explain some of the inconsistency in reports about their relationship and encourage additional studies to understand the mechanisms underlying it. |
| Databáze: | OpenAIRE |
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