Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury
| Autor: | Nafsika Poulia, Nevena Djogo, Horst Weller, Darko Ciric, Gabrielle Loers, Melitta Schachner, Florentia Papastefanaki, Florian Schulz, Tamara Martinovic, Rebecca Matsas, Tobias Vossmeyer, Igor Jakovcevski |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
drug effects [Recovery of Function]
chemistry [Coated Materials Biocompatible] Central nervous system chemistry [Gold] Metal Nanoparticles Polyethylene glycol Hindlimb Pharmacology pharmacology [Polyethylene Glycols] Polyethylene Glycols chemistry.chemical_compound Mice Drug Delivery Systems Coated Materials Biocompatible drug therapy [Spinal Cord Injuries] PEG ratio Drug Discovery chemistry [Metal Nanoparticles] Genetics Medicine Animals ddc:610 Spinal cord injury Molecular Biology Spinal Cord Injuries pharmacology [Coated Materials Biocompatible] business.industry pharmacology [Gold] methods [Drug Delivery Systems] Recovery of Function Motor neuron medicine.disease 3. Good health Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure chemistry [Polyethylene Glycols] chemistry Toxicity Drug delivery Molecular Medicine Original Article Female Gold business |
| Zdroj: | Molecular therapy 23(6), 993-1002 (2015). doi:10.1038/mt.2015.50 |
| DOI: | 10.1038/mt.2015.50 |
| Popis: | Failure of the mammalian central nervous system (CNS) to regenerate effectively after injury leads to mostly irreversible functional impairment. Gold nanoparticles (AuNPs) are promising candidates for drug delivery in combination with tissue-compatible reagents, such as polyethylene glycol (PEG). PEG administration in CNS injury models has received interest for potential therapy, but toxicity and low bioavailability prevents clinical application. Here we show that intraspinal delivery of PEG-functionalized 40-nm-AuNPs at early stages after mouse spinal cord injury is beneficial for recovery. Positive outcome of hind limb motor function was accompanied by attenuated inflammatory response, enhanced motor neuron survival, and increased myelination of spared or regrown/sprouted axons. No adverse effects, such as body weight loss, ill health, or increased mortality were observed. We propose that PEG-AuNPs represent a favorable drug-delivery platform with therapeutic potential that could be further enhanced if PEG-AuNPs are used as carriers of regeneration-promoting molecules. |
| Databáze: | OpenAIRE |
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