Development of Iron-Doped Silicon Nanoparticles As Bimodal Imaging Agents
| Autor: | Mani P. Singh, Saeed Kamali, Chuqiao Tu, Elayaraja Muthuswamy, Angelique Y. Louie, Tonya M. Atkins, Susan M. Kauzlarich |
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| Rok vydání: | 2012 |
| Předmět: |
Silicon
Photoluminescence Materials science Hydrosilylation Iron Analytical chemistry Contrast Media General Physics and Astronomy Nanoparticle chemistry.chemical_element Quantum yield Article law.invention Allylamine chemistry.chemical_compound law Cell Line Tumor Humans General Materials Science Electron paramagnetic resonance Echo-Planar Imaging Liver Neoplasms General Engineering Microscopy Fluorescence chemistry Transmission electron microscopy Nanoparticles Nuclear chemistry |
| Zdroj: | ACS Nano. 6:5596-5604 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/nn301536n |
| Popis: | We demonstrate the synthesis of water-soluble allylamine-terminated Fe-doped Si (Si(xFe)) nanoparticles as bimodal agents for optical and magnetic imaging. The preparation involves the synthesis of a single-source iron-containing precursor, Na(4)Si(4) with x% Fe (x = 1, 5, 10), and its subsequent reaction with NH(4)Br to produce hydrogen-terminated Si(xFe) nanoparticles. The hydrogen-capped nanoparticles are further terminated with allylamine via thermal hydrosilylation. Transmission electron microscopy indicates that the average particle diameter is ∼3.0 ± 1.0 nm. The Si(5Fe) nanoparticles show strong photoluminescence quantum yield in water (∼10%) with significant T(2) contrast (r(2)/r(1) value of 4.31). Electron paramagnetic resonance and Mössbauer spectroscopies indicate that iron in the nanoparticles is in the +3 oxidation state. Analysis of cytotoxicity using the resazurin assay on HepG2 liver cells indicates that the particles have minimal toxicity. |
| Databáze: | OpenAIRE |
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