Hyperuricemia and Hypertension, Coronary Artery Disease, Kidney Disease: From Concept to Practice

Autor: Michel Galinier, François Diévart, Stéphane Sadrin, Mélanie Gaubert, J M Maixent, Thomas Bardin, Alain Cohen-Solal, Régis Guieu, Franck Paganelli, Jean-Pierre Fauvel
Přispěvatelé: Hôpital Nord [CHU - APHM], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Villette Private Hospital, Hospices Civils de Lyon (HCL), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Henri Laborit (CHL), Hôpital de Rangueil, CHU Toulouse [Toulouse], Service de cardiologie [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Guieu, régis
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
serum uric acid
[SDV]Life Sciences [q-bio]
Renal function
Type 2 diabetes
Coronary Artery Disease
Review
hyperuricemia
030204 cardiovascular system & hematology
Catalysis
Inorganic Chemistry
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Framingham Heart Study
renal disease
cardiovascular disease
Internal medicine
medicine
Animals
Humans
030212 general & internal medicine
Hyperuricemia
Longitudinal Studies
Physical and Theoretical Chemistry
Renal Insufficiency
Chronic
Molecular Biology
Spectroscopy
business.industry
Organic Chemistry
General Medicine
medicine.disease
3. Good health
Computer Science Applications
[SDV] Life Sciences [q-bio]
Blood pressure
chemistry
Diabetes Mellitus
Type 2
Hypertension
Cardiology
Uric acid
business
Kidney disease
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (11), pp.4066. ⟨10.3390/ijms21114066⟩
International Journal of Molecular Sciences, 2020, 21 (11), pp.4066. ⟨10.3390/ijms21114066⟩
ISSN: 1422-0067
1661-6596
DOI: 10.3390/ijms21114066⟩
Popis: International audience; Since the publication of the Framingham Heart Study, which suggested that uric acid should no longer be associated with coronary heart disease after additional adjustment for cardiovascular disease risk factors, the number of publications challenging this statement has dramatically increased. The aim of this paper was to review and discuss the most recent studies addressing the possible relation between sustained elevated serum uric acid levels and the onset or worsening of cardiovascular and renal diseases. Original studies involving American teenagers clearly showed that serum uric acid levels were directly correlated with systolic and diastolic pressures, which has been confirmed in adult cohorts revealing a 2.21-fold increased risk of hypertension. Several studies involving patients with coronary artery disease support a role for serum uric acid level as a marker and/or predictor for future cardiovascular mortality and long-term adverse events in patients with coronary artery disease. Retrospective analyses have shown an inverse relationship between serum uric acid levels and renal function, and even a mild hyperuricemia has been shown to be associated with chronic kidney disease in patients with type 2 diabetes. Interventional studies, although of small size, showed that uric acid (UA)-lowering therapies induced a reduction of blood pressure in teenagers and a protective effect on renal function. Taken together, these studies support a role for high serum uric acid levels (>6 mg/dL or 60 mg/L) in hypertension-associated morbidities and should bring awareness to physicians with regards to patients with chronic hyperuricemia.
Databáze: OpenAIRE
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