Identification of proteins in excretory/secretory extracts of Echinostoma friedi (Trematoda) from chronic and acute infections
| Autor: | Dolores Bernal, Rafael Toledo, Ana Espert, José Enrique De la Rubia, José Guillermo Esteban, Antonio Marcilla, Inés Carpena |
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| Rok vydání: | 2006 |
| Předmět: |
Proteomics
Molecular Sequence Data Biology Biochemistry Species Specificity Heat shock protein Cricetinae Echinostoma Animals Amino Acid Sequence Rats Wistar Cytoskeleton Molecular Biology Peptide sequence Echinostomiasis Mesocricetus Aldolase A Proteins Tropomyosin Hsp70 Rats Disease Models Animal Secretory protein Acute Disease Chronic Disease biology.protein |
| Zdroj: | Proteomics. 6(9) |
| ISSN: | 1615-9853 |
| Popis: | In the present study, we describe the investigation of Echinostoma friedi excretory/secretory products using a proteomic approach combined with the use of heterologous antibodies. We have identified 18 protein spots corresponding to ten proteins, including cytoskeletal proteins like actin, tropomyosin, and paramyosin; glycolytic enzymes like enolase, glyceraldehyde 3P dehydrogenase, and aldolase; detoxifying enzymes like GSTs; and stress proteins like heat shock protein (Hsp) 70. Among these proteins, both actin and, to a lesser extent, Hsp70, exhibited differential expression patterns between chronic and acute infections in the Echinostoma-rodent model, suggesting that these proteins may play a role in the survival within the host. |
| Databáze: | OpenAIRE |
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