Transport of HDL cholesterol esters to the liver is not diminished by probucol treatment in rats
| Autor: | Ray C. Pittman, M A Pfeuffer, B M Richard |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B Probucol chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Animals HDL particle Particle Size biology Apolipoprotein A-I Cholesterol Catabolism Reverse cholesterol transport Cholesterol HDL Biological Transport Rats Inbred Strains Metabolism Rats Endocrinology chemistry Liver biology.protein lipids (amino acids peptides and proteins) Female Cholesterol Esters Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Arteriosclerosis and thrombosis : a journal of vascular biology. 12(7) |
| ISSN: | 1049-8834 |
| Popis: | This study examined the relation of decreased high density lipoprotein (HDL) levels in probucol-fed rats and the transport of HDL cholesterol esters (CEs) to the liver. HDLs from both control rats and rats fed 1% probucol for 3 weeks were doubly labeled in their CE and apolipoprotein A-I moieties with intracellularly trapped tracers and then intravenously injected into probucol-fed or control rats for determination of plasma decay kinetics and sites of tracer uptake. Results for HDL from control and probucol-fed rats were not different. The fractional catabolic rate (FCR) of plasma HDL CE was significantly increased by probucol feeding (23%) so that mass transport of HDL CE through the plasma compartment was not significantly different from that in control rats. The plasma FCR for apolipoprotein A-I did not change. Similarly, the FCR for uptake of HDL CE by the liver increased on probucol feeding (20%), resulting in a near-normal rate of HDL CE mass uptake, whereas the FCR for HDL particle uptake (measured by apolipoprotein A-I uptake) did not change. Thus, the maintenance of near-normal HDL CE uptake by the liver was exclusively due to increased selective uptake (32%). To the extent that hepatic uptake of HDL CE mediates reverse cholesterol transport, that process was not significantly compromised in rats fed 1% probucol. |
| Databáze: | OpenAIRE |
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