Influenza vaccination in healthcare workers; comparison of side effects and preferred route of administration of intradermal versus intramuscular administration

Autor: W.J. Meijer, Jan Wilschut, Annelies Riezebos-Brilman, M.J.T. de Vries, J.C.F. Kuiphuis, Annemarie M. J. Wensing, E.M.M. Hagelen, Antoine Bos
Přispěvatelé: Microbes in Health and Disease (MHD)
Rok vydání: 2017
Předmět:
Male
IMMUNOGENICITY
0302 clinical medicine
Surveys and Questionnaires
Health care
University medical
Prospective Studies
030212 general & internal medicine
Prospective cohort study
Netherlands
Academic Medical Centers
Health care workers
Vaccination
Middle Aged
Infectious Diseases
Influenza Vaccines
SAFETY
Molecular Medicine
TRIAL
Female
Adult
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions
Health Personnel
030231 tropical medicine
Injections
Intramuscular
Young Adult
03 medical and health sciences
Route of administration
AGE
Intradermal
VACCINES
Internal medicine
Influenza
Human
medicine
Humans
Adverse effect
Administration
Intranasal
Aged
Questionnaire study
General Veterinary
General Immunology and Microbiology
business.industry
Public Health
Environmental and Occupational Health
Influenza
Immunology
ADVERSE EVENTS
business
Vaccine
Zdroj: Vaccine, 35(11), 1517-1523. ELSEVIER SCI LTD
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2017.01.065
Popis: To explore the nature and severity of side effects and future preference of intradermal versus intramuscular influenza vaccination in healthcare workers.Prospective cohort study.Two University Medical Centers in The Netherlands.Healthcare workers receiving an influenza vaccination.Healthcare workers that were vaccinated during the influenza vaccination season of 2012-2013 were approached for participation in a questionnaire study. The questionnaire was divided into two parts. The first part had to be answered directly after vaccination and the second part two weeks after vaccination. The motivation for vaccine uptake, whether or not the HCWs had direct contact with patients and the prevalence and severity of local and systemic side effects of influenza vaccination were explored. In addition, it was assessed how participants experienced the vaccination and which type of administration they preferred for future vaccination.Side effects of vaccination were more prevalent in the intradermal group versus the intramuscular group (56% versus 26%, p0.001). Local side effects were perceived as more severe in healthcare workers receiving the intradermal vaccine. Directly after vaccination, healthcare workers preferred the intradermal vaccination. Two weeks after vaccination both types of vaccine were equally appreciated.This study shows that there are significant differences in the nature and severity of side effects upon intramuscular and intradermal influenza vaccination. This difference did not result in a preference among the vaccinated subjects for one type of vaccine.
Databáze: OpenAIRE
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