Head-to-Head Comparison of Inflammation and Neovascularization in Human Carotid Plaques
| Autor: | Jean-Louis Vanoverschelde, Agnes Pasquet, Bernhard Gerber, David Vancraeynest, Fabian Demeure, Robert Verhelst, Anne Bol, Christophe de Meester, Parla Astarci, Véronique Roelants, Caroline Bouzin, Anne-Catherine Pouleur |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty Head to head Contrast Media Inflammation 030204 cardiovascular system & hematology Neovascularization 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography medicine Humans Carotid Stenosis Radiology Nuclear Medicine and imaging Prospective Studies Aged Ultrasonography Positron Emission Tomography-Computed Tomography Neovascularization Pathologic business.industry Plaque Atherosclerotic Carotid Arteries Female Radiopharmaceuticals medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Plaque inflammation |
| Zdroj: | Circulation: Cardiovascular Imaging. 10 |
| ISSN: | 1942-0080 1941-9651 |
| DOI: | 10.1161/circimaging.116.005846 |
| Popis: | Background— Inflammation and intraplaque neovascularization are acknowledged to be 2 features of plaque vulnerability, although their temporal expression and their respective value in predicting clinical events are poorly understood. To determine their respective temporal associations, we conducted a comprehensive assessment of inflammation and intraplaque neovascularization in the carotid plaque of symptomatic and asymptomatic patients. Methods and Results— Thirty patients with severe carotid stenosis underwent 18 F-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging. Plaque 18 F-fluorodeoxyglucose-uptake, indicative of inflammation, was measured by calculating the target:background ratio. The presence of intraplaque neovascularization during contrast-enhanced ultrasound was judged semiquantitatively; low-grade contrast enhancement (CE) suggested its absence, and high-grade CE, the presence of neovascularization. Carotid surgery was performed 1.6±1.8 days after completing both imaging modalities in all patients, and the presence of macrophages and neovessels was quantified by immunohistochemistry. We identified a significant correlation between the target:background ratio and macrophage quantification ( R =0.78; P P P =0.28 and P =0.60, respectively) nor macrophage infiltration ( P =0.59 and P =0.40, respectively). Finally, macrophage infiltration and target:background ratio were higher in the carotid plaque of symptomatic patients ( P =0.021 and P =0.05, respectively), whereas CE grade and the presence of neovessels were not. Conclusions— Inflammation and intraplaque neovascularization are not systematically associated in carotid plaques, suggesting a temporal separation between the 2 processes. Inflammation seems more pronounced when symptoms are present. These data highlight the challenges that face any imaging strategy designed to assess plaque vulnerability. |
| Databáze: | OpenAIRE |
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