Scleromyxedematous Changes in a Patient With Long-Standing Mycosis Fungoides Who Progressed to Sézary Syndrome
| Autor: | Patricia L. Myskowski, Shamir Geller, Melissa Pulitzer, Allen P. Miraflor |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Mycosis fungoides Follicular mucinosis Skin Neoplasms business.industry medicine.medical_treatment Dermatology General Medicine medicine.disease Article Mucinosis Pathology and Forensic Medicine Neoplasms Multiple Primary Radiation therapy 030207 dermatology & venereal diseases 03 medical and health sciences Mycosis Fungoides 0302 clinical medicine medicine Humans Sezary Syndrome business Aged |
| Zdroj: | Am J Dermatopathol |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000001464 |
| Popis: | Mycosis fungoides (MF) variants with different clinicopathologic and immunohistochemical features have been well-delineated. We report a case of scleromyxedematous changes arising in a patient with long-standing MF who progressed to Sézary syndrome (SS) shortly afterwards. Total skin electron beam (TSEB) radiation therapy resulted in an excellent response, controlling both the MF/SS and the scleromyxedematous lesions; however, the patient expired few months later. Although mucin deposition has been described in association with MF/SS [mainly follicular mucinosis in folliculotropic MF], there are limited reports in the literature on dermal mucinosis and scleromyxedematous changes in MF/SS. The mechanism of this association and its prognostic implications require further investigation. |
| Databáze: | OpenAIRE |
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