Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis
| Autor: | Sarah Malek, Zeev Schwartz, Susan L. Schaefer, Brett Nemke, Gerianne Holzman, Jason A. Bleedorn, Peter Muir, Elizabeth M Cozzi, Peer B Jacobson, Susannah J. Sample |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Carprofen Lameness Animal Osteoarthritis Outcome measures Osteoarthritis Hip Body Temperature law.invention Randomized controlled trial Heart Rate law Dog Medicine Dog Diseases Tramadol lcsh:Veterinary medicine medicine.diagnostic_test Respiration Anti-Inflammatory Agents Non-Steroidal ABT-116 General Medicine Analgesics Opioid Clinical trial Treatment Outcome Anesthesia Female Research Article medicine.drug Indazoles Analgesic Carbazoles Pain Physical examination Placebo Dogs Double-Blind Method Animals Hip General Veterinary business.industry Phenylurea Compounds Placebo Effect medicine.disease veterinary(all) lcsh:SF600-1100 business |
| Zdroj: | BMC Veterinary Research, Vol 8, Iss 1, p 185 (2012) BMC Veterinary Research |
| ISSN: | 1746-6148 |
| Popis: | Background Pain and impaired mobility because of osteoarthritis (OA) is common in dogs and humans. Efficacy studies of analgesic drug treatment of dogs with naturally occurring OA may be challenging, as a caregiver placebo effect is typically evident. However, little is known about effect sizes of common outcome-measures in canine clinical trials evaluating treatment of OA pain. Forty-nine client-owned dogs with hip OA were enrolled in a randomized, double-blinded placebo-controlled prospective trial. After a 1 week baseline period, dogs were randomly assigned to a treatment (ABT-116 – transient receptor potential vanilloid 1 (TRPV1) antagonist, Carprofen – non-steroidal anti-inflammatory drug (NSAID), Tramadol - synthetic opiate, or Placebo) for 2 weeks. Outcome-measures included physical examination parameters, owner questionnaire, activity monitoring, gait analysis, and use of rescue medication. Results Acute hyperthermia developed after ABT-116 treatment (P < 0.001). Treatment with carprofen (P ≤ 0.01) and tramadol (P ≤ 0.001) led to improved mobility assessed by owner questionnaire. Nighttime activity was increased after ABT-116 treatment (P = 0.01). Kinetic gait analysis did not reveal significant treatment effects. Use of rescue treatment decreased with treatment in the ABT-116 and Carprofen groups (P < 0.001). Questionnaire score and activity count at the end of treatment were correlated with age, clinical severity at trial entry, and outcome measure baseline status (SR ≥ ±0.40, P ≤ 0.005). Placebo treatment effects were evident with all variables studied. Conclusion Treatment of hip OA in client-owned dogs is associated with a placebo effect for all variables that are commonly used for efficacy studies of analgesic drugs. This likely reflects caregiver bias or the phenomenon of regression to the mean. In the present study, outcome measures with significant effects also varied between groups, highlighting the value of using multiple outcome measures, as well as an a priori analysis of effect size associated with each measure. Effect size data from the present study could be used to inform design of future trials studying analgesic treatment of canine OA. Our results suggest that analgesic treatment with ABT-116 is not as effective as carprofen or tramadol for treatment of hip arthritis pain in client-owned dogs. |
| Databáze: | OpenAIRE |
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