Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families
| Autor: | Häppölä, Paavo, Gormley, Padhraig, Nuottamo, Marjo E., Artto, Ville, Sumelahti, Marja Liisa, Nissilä, Markku, Keski-Säntti, Petra, Ilmavirta, Matti, Kaunisto, Mari A., Hämäläinen, Eija I., Ripatti, Samuli, Pirinen, Matti, Wessman, Maija, Palotie, Aarno, Kallela, Mikko, Hansen, Thomas Folkmann, Olesen, Jes |
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| Přispěvatelé: | Tampere University, Tays Research Services, Clinical Medicine, Complex Disease Genetics, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, Helsinki Institute of Life Science HiLIFE, Clinicum, Neurologian yksikkö, HUS Neurocenter, HUS Helsinki and Uusimaa Hospital District, University of Helsinki, Centre of Excellence in Complex Disease Genetics, Department of Public Health, Samuli Olli Ripatti / Principal Investigator, Faculty Common Matters (Faculty of Social Sciences), Biostatistics Helsinki, Helsinki Institute for Information Technology, Statistical and population genetics, Department of Mathematics and Statistics, Biosciences, Aarno Palotie / Principal Investigator, Department of Neurosciences |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Headache Disorders Migraine Disorders Migraine with Aura Consensus criteria Disease DISEASE 3124 Neurology and psychiatry 03 medical and health sciences 0302 clinical medicine Humans Medicine Psychiatry Finland Migraine 030304 developmental biology 0303 health sciences business.industry Headache General Medicine medicine.disease 3142 Public health care science environmental and occupational health 3. Good health polygenic risk score International Classification of Headache Disorders Polygenic risk score Neurology (clinical) diagnosis criteria business headache 030217 neurology & neurosurgery |
| Zdroj: | Häppölä, P, Gormley, P, Nuottamo, M E, Artto, V, Sumelahti, M L, Nissilä, M, Keski-Säntti, P, Ilmavirta, M, Kaunisto, M A, Hämäläinen, E I, Ripatti, S, Pirinen, M, Wessman, M, Palotie, A, Kallela, M, International Headache Genetics Consortium (IHGC), Hansen, T F & Olesen, J 2022, ' Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families ', Cephalalgia, vol. 42, no. 4-5, pp. 345-356 . https://doi.org/10.1177/03331024211045651 |
| Popis: | Background Migraine is diagnosed using the extensively field-tested International Classification of Headache Disorders (ICHD-3) consensus criteria derived by the International Headache Society. To evaluate the criteria in respect to a measurable biomarker, we studied the relationship between the main ICHD-3 criteria and the polygenic risk score, a measure of common variant burden in migraine. Methods We used linear mixed models to study the correlation of ICHD-3 diagnostic criteria, underlying symptoms, and main diagnoses with the polygenic risk score of migraine in a cohort of 8602 individuals from the Finnish Migraine Genome Project. Results Main diagnostic categories and all underlying diagnostic criteria formed a consistent continuum along the increasing polygenic burden. Polygenic risk was associated with the heterogeneous clinical picture starting from the non-migraine headache (mean 0.07; 95% CI 0.02–0.12; p = 0.008 compared to the non-headache group), to probable migraine (mean 0.13; 95% CI 0.08–0.18; p Conclusions The complex migraine phenotype progressively follows the polygenic burden from individuals with no headache to non-migrainous headache and up to patients with attacks manifesting all the features of the ICHD-3 headache and aura. Results provide further biological support for the ICHD-3 diagnostic criteria. |
| Databáze: | OpenAIRE |
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