Treatment of ankylosing spondylitis with biologics and targeted physical therapy: positive effect on chest pain, diminished chest mobility, and respiratory function
| Autor: | Zoltán Szekanecz, Sándor Szántó, Nóra Bodnár, Zsuzsanna Némethné Gyurcsik |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Vital capacity medicine.medical_specialty Chest Pain Klinikai orvostudományok Chest pain Rheumatology medicine Back pain Humans Respiratory function Spondylitis Ankylosing Spondylitis BASDAI Physical Therapy Modalities Ankylosing spondylitis Biological Products business.industry Orvostudományok Middle Aged medicine.disease Respiration Disorders Combined Modality Therapy Treatment Outcome Physical therapy Female medicine.symptom BASFI business |
| Zdroj: | Zeitschrift fur Rheumatologie. 72(10) |
| ISSN: | 1435-1250 |
| Popis: | Biologics are highly effective in ankylosing spondylitis (AS). In this self-controlled study, we assessed the additive value of complex physiotherapy in decreasing chest pain and tenderness and improving respiratory function in AS patients treated with tumor necrosis factor α (TNF-α) inhibitors. The trial consisted of 2 parts. In study I, clinical data of AS patients with (n = 55) or without biological therapy (n = 20) were retrospectively analyzed and compared. Anthropometrical data, duration since diagnosis and patient assessment of disease activity, pain intensity, tender points, sacroiliac joint involvement determined by X-ray, functional condition, and physical activity level were recorded. Subjective, functional, and physical tests were performed. In study II, 10 voluntary patients (6 men and 4 women, age 52.4 ± 13.6 years) with definite AS and receiving anti-TNF therapy were recruited. It was a prospective, non-randomized physiotherapeutic trial. BASFI (Bath Ankylosing Spondylitis Functional Index), BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), modified Schober Index, occiput-to-wall distance, and fingertip-to-floor distance were evaluated. Forced vital capacity, forced 1-s expiratory volume, peak expiratory flow, and maximum voluntary ventilation were recorded. Furthermore, typical tender points were recorded. A targeted physiotherapy program was conducted twice a week for 12 weeks and all above parameters were recorded at baseline and after 12 weeks. Differences in patient assessment of disease activity (p = 0.019) and pain intensity (p = 0.017) were found in study I. Pain and tenderness of the thoracic spine were observed in both groups. Back pain without biologic therapy was slightly higher than other group. In study II, we found that patient assessment of disease activity and pain intensity significantly improved after the physical therapy program (p = 0.002 and p |
| Databáze: | OpenAIRE |
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