Gadolinium neutron capture in glioblastoma multiforme cells

Autor:	T. Kroc, Linda Schneider, Christine Andorf, Linda S. Yasui, Arlene Lennox, K.R. Saroja
Rok vydání:	2008
Předmět:	inorganic chemicals Gadolinium DTPA Materials science Cell Survival Astrophysics::High Energy Astrophysical Phenomena Gadolinium medicine.medical_treatment Physics::Medical Physics Nuclear Theory chemistry.chemical_element Cell Line Tumor medicine Humans Radiology Nuclear Medicine and imaging Irradiation Nuclear Experiment Clonogenic assay Fast neutron therapy Neutrons integumentary system Radiological and Ultrasound Technology Brain Neoplasms Radiochemistry technology industry and agriculture Neutron radiation Neutron temperature Neutron capture Cell killing chemistry Gamma Rays biological sciences lipids (amino acids peptides and proteins) Glioblastoma
Zdroj:	International journal of radiation biology. 84(12)
ISSN:	0955-3002
Popis:	A proof of principle for cell killing by Gadolinium (Gd) neutron capture in Magnevist preloaded Glioblastoma multiforme (GBM) cells is provided.U87cells were pre-loaded with 5 mg/ml Magnevist (Gd containing compound) and irradiated using an enhanced neutron beam developed at NIU Institute for Neutron Therapy at Fermilab. These experiments were possible because of an enhanced fast neutron therapy assembly designed to use the fast neutron beam at Fermilab to deliver a neutron beam containing a greater fraction of thermal neutrons and because of the development of improved calculations for dose for the enhanced neutron beam. Clonogenic response was determined.U87 cell survival after gamma irradiation, fast neutron irradiation and irradiation with the enhanced neutron beam in the presence or absence of Magnevist were determined.U87 cells were the least sensitive to gamma radiation, and increasingly sensitive to fast neutron irradiation, irradiation with the enhanced neutron beam and finally a significant enhancement in cell killing was observed for U87 cells preloaded with Magnevist. The sensitivity of U87 cells pre-loaded with Magnevist and then irradiated with the enhanced neutron beam can at least in part be attributed to the Auger electrons emitted by the neutron capture event.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86e1ecc1b81a0089e581c688b9931ae https://pubmed.ncbi.nlm.nih.gov/19061138 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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