Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers

Autor: Alexandre E Voskuyl, Adriaan A. Lammertsma, M. C. Huisman, N. J. F. Verweij, Otto S. Hoekstra, P.M. van de Ven, C.J. van der Laken, Albert D. Windhorst, Stefan T G Bruijnen, Michael Kassiou, Y. Y. J. Gent
Přispěvatelé: Rheumatology, Dermatology, AII - Inflammatory diseases, Epidemiology and Data Science, APH - Aging & Later Life, APH - Societal Participation & Health, Radiology and nuclear medicine, CCA - Cancer Treatment and quality of life, APH - Methodology, ACS - Heart failure & arrhythmias
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Physiology
NSAIDs
Macrophage targeting
Arthritis
Diagnostic Radiology
Arthritis
Rheumatoid
White Blood Cells
0302 clinical medicine
Skeletal Joints
Animal Cells
Positron Emission Tomography Computed Tomography
Medicine and Health Sciences
Medicine
Musculoskeletal System
Tomography
Analgesics
Multidisciplinary
medicine.diagnostic_test
biology
Radiology and Imaging
Drugs
Wrist
Middle Aged
Body Fluids
Molecular Imaging
Arms
Blood
Positron emission tomography
Rheumatoid arthritis
Female
Anatomy
Cellular Types
Research Article
Imaging Techniques
Hand Joints
Immune Cells
Science
Immunology
Neuroimaging
Rheumatoid Arthritis
Research and Analysis Methods
Proof of Concept Study
Imaging data
Autoimmune Diseases
Disease activity
03 medical and health sciences
Rheumatology
Receptors
GABA
Diagnostic Medicine
Translocator protein
Humans
Aged
Pharmacology
030203 arthritis & rheumatology
Blood Cells
business.industry
Macrophages
fungi
Biology and Life Sciences
Cell Biology
Isoquinolines
medicine.disease
Amides
Pain management
Hand joint
Early Diagnosis
Pyrimidines
Body Limbs
biology.protein
Pyrazoles
Clinical Immunology
Clinical Medicine
Radiopharmaceuticals
business
Nuclear medicine
Positron Emission Tomography
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 14, Iss 9, p e0222844 (2019)
Bruijnen, S T G, Verweij, N J F, Gent, Y Y J, Huisman, M C, Windhorst, A D, Kassiou, M, van de Ven, P M, Lammertsma, A A, Hoekstra, O S, Voskuyl, A E & van der Laken, C J 2019, ' Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers ', PLoS ONE, vol. 14, no. 9, e0222844 . https://doi.org/10.1371/journal.pone.0222844
PLoS ONE
PLoS ONE, 14(9):e0222844. Public Library of Science
ISSN: 1932-6203
Popis: Background Positron emission tomography (PET) imaging of macrophages using the translocator protein (TSPO) tracer (R)-[11C]PK11195 has shown the promise to image rheumatoid arthritis (RA). To further improve TSPO PET for RA imaging, second generation TSPO tracers [11C]DPA-713 and [18F]DPA-714 have recently been evaluated pre-clinically showing better imaging characteristics. Objective A clinical proof of concept study to evaluate [11C]DPA-713 and [18F]DPA-714 to visualize arthritis in RA patients. Methods RA patients (n = 13) with at least two active hand joints were included. PET/CT scans of the hands were obtained after injection of [18F]DPA-714, [11C]DPA-713 and/or (R)-[11C]PK11195 (max. 2 tracers pp). Standardized uptake values (SUVs) and target-to-background (T/B) ratios were determined. Imaging data of the 3 different tracers were compared by pooled post-hoc testing, and by a head to head comparison. Results Clinically active arthritis was present in 110 hand joints (2–17 pp). Arthritic joints were visualized with both [11C]DPA-713 and [18F]DPA-714. Visual tracer uptake corresponded with clinical signs of arthritis in 80% of the joints. Mean absolute uptake in PET-positive joints was significantly higher for [11C]DPA-713 than for [18F]DPA-714, the latter being not significantly different from (R)-[11C]PK11195 uptake. Background uptake was lower for both DPA tracers compared with that of (R)-[11C]PK11195. Higher absolute uptake and lower background resulted in two-fold higher T/B ratios for [11C]DPA-713. Conclusions [11C]DPA-713 and [18F]DPA-714 visualize arthritic joints in active RA patients and most optimal arthritis imaging results were obtained for [11C]DPA-713. Second generation TSPO macrophage PET provides new opportunities for both early diagnosis and therapy monitoring of RA.
Databáze: OpenAIRE
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