Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China

Autor: Ke-Ren Shan, Ting Zhang, Zhi-Zhong Guan, Yan He, Kui Tan, Chan Zhang, Chan-Juan Wang
Rok vydání: 2017
Předmět:
Male
gene polymorphisms
0301 basic medicine
Medicine (General)
Glucuronosyltransferase
Gene Expression
medicine.disease_cause
Biochemistry
chemistry.chemical_compound
Chemokine receptor
hepatitis B virus infection
Gene Frequency
Genotype
Ethnicity
biology
virus diseases
General Medicine
Middle Aged
Hepatitis B
Female
C-C motif chemokine receptor 5 (CCR5)
Adult
Risk
China
Hepatitis B virus
Heterozygote
Receptors
CCR5
ethnic minorities
Polymorphism
Single Nucleotide
03 medical and health sciences
R5-920
medicine
Humans
Genetic Predisposition to Disease
Allele
Gene
Genotyping
Alleles
uridine diphosphate-glucuronosyltransferase 1A (UGT-1A)
Biochemistry (medical)
Research Reports
Sequence Analysis
DNA
Cell Biology
Virology
Uridine diphosphate
030104 developmental biology
chemistry
Case-Control Studies
biology.protein
Zdroj: Journal of International Medical Research, Vol 46 (2018)
The Journal of International Medical Research
ISSN: 1473-2300
0300-0605
DOI: 10.1177/0300060517730174
Popis: Objective To determine whether genetic polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A ( UGT1A) and the C-C motif chemokine receptor 5 ( CCR5) genes are associated with hepatitis B virus (HBV) infection in Yi, Yao and Han ethnic groups in the Guizhou Province of China. Methods The study enrolled subjects with and without HBV infection. Whole blood was used for DNA genotyping using standard techniques. The study determined the frequencies of several polymorphic alleles ( UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5Δ32 [rs333]) and then characterized their relationship with HBV infection. Results A total of 404 subjects were enrolled in the study: 138 from the Yao group, 101 from the Yi group and 165 from the Han group. There was a significant difference in the frequency of UGT1A1 rs8175347 polymorphisms among the three groups. The rates of 7TA carriers of UGT1A1 rs8175347 in all three groups were significantly higher than the other genotypes. Individuals with genotype AA of UGT1A6 rs2070959 in the Yi group had a higher risk for HBV infection than in the Yao and Han groups. The frequency of genotype GG in CCR5-59029 in the Yao group was significantly higher than in the Yi group. The genotypes of CCR5Δ32 were not associated with HBV infection. Conclusion These findings provide genetic and epidemiological evidence for an association of UGT1A and CCR5-59029 polymorphisms with HBV infection in Chinese Yi and Yao populations.
Databáze: OpenAIRE
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