Regulation of Pancreatic Islet Formation

Autor:	Franz Martín, M.C. Martínez Carrasco, Irene Delgado, Anabel Rojas, Francisco J. Bedoya, Nadia Cobo Vuilleumier, Juan R. Tejedo, Bernat Soria, Benoit R. Gauthier
Rok vydání:	2014
Předmět:	medicine.medical_specialty geography Type 1 diabetes geography.geographical_feature_category Pancreatic islets Type 2 diabetes Biology Islet medicine.disease In vitro Cell biology medicine.anatomical_structure Endocrinology In vivo Internal medicine Diabetes mellitus medicine Pancreas
Zdroj:	Islets of Langerhans ISBN: 9789400766853 Islets of Langerhans, 2. ed. ISBN: 9789400768840
DOI:	10.1007/978-94-007-6686-0_36
Popis:	Pancreatic islets are complex structures formed by five different hormoneexpressing cells surrounded by endothelial cells, nerves, and fibroblasts. Dysfunction of insulin-producing cells (β-cells) causes diabetes. Generation of β-like cells that can compensate the loss of β-cell mass in type 1 diabetes or defects in β-cell insulin secretion in type 2 diabetes is a current challenge in biomedicine. The knowledge of the molecular basis governing pancreas development and islet formation will help us to generate in vitro or in vivo
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d854156bad0aca70ff92c6014057869b https://doi.org/10.1007/978-94-007-6686-0_36 Zobrazit plný text záznamu