Systems immunology reveals a linked IgG3–C4 response in patients with acute rheumatic fever
| Autor: | Susanne Tritscheller, William John Martin, Jeremy M Raynes, Natalie Lorenz, Timothy Kc Ho, Nigel Wilson, Mei Lin Tay, Alana L. Whitcombe, Amy W. Chung, Reuben McGregor, Nicole J. Moreland, Michael G Baker, Jason Gurney, Deborah A Williamson, Paulina Hanson-Manful, Cristin G. Print, Jane Oliver |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Adolescent Immunology Inflammation Immunoglobulin G Pathogenesis 03 medical and health sciences 0302 clinical medicine Group A streptococcal infection Humans Immunology and Allergy Medicine Child biology business.industry C-reactive protein Complement C4 Cell Biology medicine.disease Immunity Humoral 030104 developmental biology Humoral immunity biology.protein Rheumatic fever Female Rheumatic Fever Antibody medicine.symptom business 030215 immunology |
| Zdroj: | Immunology & Cell Biology. 98:12-21 |
| ISSN: | 1440-1711 0818-9641 |
| DOI: | 10.1111/imcb.12298 |
| Popis: | Acute rheumatic fever (ARF) and chronic rheumatic heart disease (RHD) are autoimmune sequelae of a Group A streptococcal infection with significant global mortality and poorly understood pathogenesis. Immunoglobulin and complement deposition were observed in ARF/RHD valve tissue over 50 years ago, yet contemporary investigations have been lacking. This study applied systems immunology to investigate the relationships between the complement system and immunoglobulin in ARF. Patients were stratified by C-reactive protein (CRP) concentration into high (≥10 μg mL-1 ) and low ( |
| Databáze: | OpenAIRE |
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