High level of plasma remnant-like particle cholesterol may predispose to development of hypertension in normotensive subjects
| Autor: | Ayako Yoshimura, Yuji Hirai, Kanako Yokoi, Ako Fukami, Eri Tsukagawa, Eishi Esaki, Kuniko Yoshikawa, Sachiko Nakamura, Kinuka Ogata, Aya Obuchi, Tsutomu Imaizumi, Mika Enomoto, Hisashi Adachi, Akiko Kasahara |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Lipoproteins Population Blood Pressure Lipoprotein particle Japan Seven Countries Study Risk Factors Internal medicine Internal Medicine medicine Hyperinsulinemia Humans education Prospective cohort study Triglycerides Retrospective Studies education.field_of_study business.industry Incidence Odds ratio Fasting Middle Aged medicine.disease Postprandial Period Endocrinology Blood pressure Cholesterol Cross-Sectional Studies Cohort Hypertension Cardiology Disease Progression Female Disease Susceptibility business Follow-Up Studies |
| Zdroj: | American journal of hypertension. 26(6) |
| ISSN: | 1941-7225 |
| Popis: | BACKGROUND Remnant-like lipoprotein particle cholesterol (RLP-C) is a highly atherogenic factor. RLP-C induces endothelial dysfunction and is associated with hyperinsulinemia. This study was designed to determine whether high plasma RLP-C levels predispose to the development of hypertension in subjects with normal blood pressure (BP). METHODS A total of 1,485 subjects aged >40 years in a Japanese Cohort of the Seven Countries Study received health examinations. We examined BP, anthropometric parameters, and blood chemistries, including fasting RLP-C levels. RLP-C levels were measured by an immune-separation method. We excluded from the analysis 676 subjects who had hypertension (BP ≥ 140/90mm Hg), or were on antihypertensive medication, and/or were on antihyperlipidemic medication at baseline. Ten years later, 681 subjects were re-examined. RESULTS Of 681 normotensive subjects at baseline, 303 subjects had developed hypertension 10 years later. Baseline RLP-C level was significantly higher (P < 0.01) in the subjects who developed hypertension than in those who remained normotensive (3.7±1.9 vs. 3.3±1.6mg/dl). Multivariable logistic regression analysis demonstrated that baseline RLP-C was a significant factor for incident hypertension after adjustments for homeostasis model assessment index and other hypertension-related factors (odds ratio = 1.05, 95% CI = 1.00-1.10; P = 0.04). CONCLUSIONS A high level of plasma RLP-C in normotensive subjects may predispose to the development of hypertension in a population of community-dwelling Japanese. |
| Databáze: | OpenAIRE |
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