Coronary calcification, homocysteine, C-reactive protein and the metabolic syndrome in Type 2 diabetes: the Prospective Evaluation of Diabetic Ischaemic Heart Disease by Coronary Tomography (PREDICT) Study
| Autor: | M. Khan, Marcus Flather, William Richmond, Robert S. Elkeles, Michael D. Feher, M. B. Rubens, F. Nugara, V. Anyaoku, J. Donovan, Ian F. Godsland |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Homocysteine Endocrinology Diabetes and Metabolism Myocardial Ischemia Type 2 diabetes Coronary Artery Disease Electron beam tomography chemistry.chemical_compound Endocrinology Insulin resistance Predictive Value of Tests Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Prospective Studies Metabolic Syndrome Univariate analysis medicine.diagnostic_test biology Homocystine business.industry C-reactive protein nutritional and metabolic diseases Calcinosis Middle Aged medicine.disease C-Reactive Protein chemistry Diabetes Mellitus Type 2 Cardiology biology.protein Metabolic syndrome business Tomography X-Ray Computed Diabetic Angiopathies |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association. 23(11) |
| ISSN: | 0742-3071 |
| Popis: | Aims The PREDICT Study aims to determine: (i) the association between cardiovascular risk factors and coronary artery calcification score (CACS) obtained by electron beam tomography and (ii) the predictive value of CACS for coronary heart disease (CHD) events in Type 2 diabetes. Methods Having previously reported relationships between CACS and conventional risk factors, we have now studied the novel risk factors, plasma high-sensitivity C-reactive protein (CRP) and homocysteine, insulin resistance, serum apoprotein A1 and B concentrations, the serum triglyceride/high-density lipoprotein cholesterol ratio and metabolic syndrome (International Diabetes Federation definition) in 573 subjects of the PREDICT Type 2 diabetes cohort. Results In univariate analyses, the only significant positive novel correlate of CACS was homocysteine (P = 0.0004). CRP was increased in those with detectable calcification, but decreased with increasing calcification score (P = 0.006). In a multivariate model that included all significant univariate correlates, CACS was independently associated with age (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text