Correlates and determinants of Early Infant Diagnosis outcomes in North-Central Nigeria

Autor: Obinna Ogbanufe, Chukwuemeka Okolo, Monday Tola, Christopher Chime, Olachi Anuforom, Samuel Peters, Nicaise Ndembi, Patrick Dakum, Nta Iboro, Jibreel Jumare, Aliyu Ahmad
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: AIDS Research and Therapy
AIDS Research and Therapy, Vol 16, Iss 1, Pp 1-7 (2019)
ISSN: 1742-6405
Popis: Background A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babies which improves treatment outcomes. Objectives We explored factors associated with EID outcomes among HEI in North-Central Nigeria. Method This is a cross-sectional study using EID data of PMTCT-enrollees matched with results of HEI’s dried blood samples (DBS), processed for DNA-PCR from January 2015 through July 2017. Statistical analyses were done using SPSS version 20.0 to generate frequencies and examine associations, including binomial logistic regression with p Results Of 14,448 HEI in this analysis, 51.8% were female and 95% (n = 12,801) were breastfed. The median age of the infants at sample collection was 8 weeks (IQR 6–20), compared to HEI tested after 20 weeks of age, those tested earlier had significantly greater odds of a negative HIV result (≤ 6 weeks: OR = 3.8; 6–8 weeks: OR = 2.1; 8–20 weeks: OR = 1.5) with evidence of a significant linear trend (p Conclusions cART prior to and during pregnancy, earlier age of HEI at EID testing and alternative feeding other than breastfeeding were associated with an increased likelihood of being HIV-negative on EID. Therefore, strategies to scale-up PMTCT services are needed to mitigate the burden of HIV among children.
Databáze: OpenAIRE
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